Primary Splenic Diffuse Large B-cell Lymphoma Manifesting in Red Pulp

Overview

Journal Virchows Arch

Specialties Cell Biology
Molecular Biology
Pathology

Date 2008 Sep 27

PMID 18818942

Citations 7

Authors

Makoto Kashimura

Masahiro Noro

Bunshiro Akikusa

Atsushi Okuhara

Shuji Momose

Ikuo Miura

Masaru Kojima

Jun-Ichi Tamaru

Affiliations

Soon will be listed here.

Abstract

We evaluated six cases of diffuse large B-cell lymphoma (DLBCL) involving the red pulp of the spleen. All had B symptoms and an aggressive clinical course. The lymphoma cells proliferated diffusely and non-cohesively in the cords of the red pulp. The lymphoma involved the bone marrow in four of the five patients and the liver in all four of the patients examined. However, lymph node (LN) involvement was rare at presentation, and systemic LN involvement was not observed even in the terminal phase. The lymphoma cells infiltrated the intrasinusoidal/intravascular and interstitial spaces of the involved tissues and were detected in the peripheral blood in two of the six patients. CD5-expressing lymphoma cells were detected in four of the five patients examined. Because these cases had some unique clinical features and occurred in distinct splenic sites, we proposed that primary splenic DLBCL manifesting in red pulp is a distinct clinicopathological entity.

Citing Articles

Establishment of Prognosis Nomogram for Primary Splenic Diffuse Large B Cell Lymphoma: A Study Based on SEER Database.

Yonghao O, Yongyang W, Siqing Y, Chengchao F, Lihua C, Xin L Indian J Hematol Blood Transfus. 2024; 40(2):220-230.

PMID: 38708154 PMC: 11065835. DOI: 10.1007/s12288-023-01706-6.

Low-Grade Primary Splenic CD10-Positive Small B-Cell Lymphoma/Follicular Lymphoma.

Abdulbaki R, Tizro P, Nava V, Gomes Da Silva M, Ascensao J Curr Oncol. 2021; 28(6):4821-4831.

PMID: 34898578 PMC: 8628768. DOI: 10.3390/curroncol28060407.

Fever and arthralgia as the initial symptoms of primary bone marrow diffuse large B-cell lymphoma: A case report.

Ren S, Tao Y, Jia L, Cheng P, Zhang J, Zhang H Oncol Lett. 2016; 11(5):3428-3432.

PMID: 27123129 PMC: 4840859. DOI: 10.3892/ol.2016.4405.

Primary splenic lymphoma: a case report.

Kattepur A, Rohith S, Shivaswamy B, Babu R, Santhosh C Indian J Surg Oncol. 2014; 4(3):287-90.

PMID: 24426740 PMC: 3771062. DOI: 10.1007/s13193-013-0243-x.

Primary hepatosplenic CD5-positive diffuse large B-cell lymphoma: a case report with literature review.

Zhang X, Sun M, Zhang L, Shao H Int J Clin Exp Pathol. 2013; 6(5):985-9.

PMID: 23638236 PMC: 3638115.

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