The Phylogenic Expression of Plasmolipin in the Vertebrate Nervous System

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1991 Feb 1

PMID 1881515

Citations 2

Authors

V S Sapirstein

C E Nolan

I Fischer

E Cochary

S Blau

C J Flynn

Affiliations

Soon will be listed here.

Abstract

Plasmolipin is a plasma membrane proteolipid is a major myelin membrane component (Cochary et al., 1990). In this study we report the phylogenic expression of plasmolipin in the vertebrate nervous system. Using Western blot analysis with polyclonal antibodies, we have analyzed membrane fractions, including myelin, from elasmobranchs, teleosts, amphibians, reptiles, birds and mammals. On the basis of immune detection, plasmolipin appears to be restricted to the mammalian nervous system. Comparison of the central and peripheral nervous systems of mammals showed only minor differences in the level of plasmolipin in these two regions. Within mammals, little quantitative differences were observed when rat, human and bovine membrane fractions were compared. The late evolutionary expression of plasmolipin which results in its restriction to mammals makes it unique among the (major) myelin proteins. The potential physiologic significance of these data are discussed.

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