From the Diet to the Nucleus: Vitamin A and TGF-beta Join Efforts at the Mucosal Interface of the Intestine

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2008 Sep 24

PMID 18809338

Citations 37

Authors

Daniel Mucida

Yunji Park

Hilde Cheroutre

Affiliations

Soon will be listed here.

Abstract

The vitamin A metabolites, including retinoic acid (RA), form ligands for retinoic acid-related nuclear receptors and together they play pleiotropic roles in various biological processes. Recently, we described that RA also functions as a key modulator of transforming growth factor-beta (TGF-beta)-driven immune deviation, capable of suppressing the differentiation of interleukin-17 secreting T helper cells (T(H)17) and conversely promoting the generation of Foxp3(+) T regulatory (Treg) cells. This review will focus on the role of RA in the reciprocal TGF-beta-driven differentiation of T(H)17 and Treg and on the importance of such regulatory mechanism to control a functional immune system, in particular at the mucosal interface of the intestine.

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