Use of Animal Models to Develop Antiaddiction Medications

Overview

Journal Curr Psychiatry Rep

Publisher Current Science

Specialty Psychiatry

Date 2008 Sep 23

PMID 18803910

Citations 5

Authors

Eliot L Gardner

Affiliations

Soon will be listed here.

Abstract

Although addiction is a uniquely human phenomenon, some of its pathognomonic features can be modeled at the animal level. Such features include the euphoric "high" produced by acute administration of addictive drugs; the dysphoric "crash" produced by acute withdrawal; drug-seeking and drug-taking behaviors; and relapse to drug-seeking behavior after achieving successful abstinence. Animal models exist for each of these features. In this review, I focus on various animal models of addiction and how they can be used to search for clinically effective antiaddiction medications. I conclude by noting some of the new and novel medications that have been developed preclinically using such models and the hope for further developments along such lines.

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The selective D₃ receptor antagonist SB-277011A attenuates morphine-triggered reactivation of expression of cocaine-induced conditioned place preference.

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