Protein and Antigen Heterogeneity Among Strains of Mycoplasma Fermentans

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1991 Sep 1

PMID 1879946

Citations 5

Authors

C T Stadtlander

C Zuhua

H L Watson

G H Cassell

Affiliations

Soon will be listed here.

Abstract

The proteins and antigens of three strains of Mycoplasma fermentans were compared with those of a mycoplasma, designated "Mycoplasma incognitus," recently identified in tissues of AIDS patients. Previous studies have shown that "M. incognitus" is most likely not a new species but rather a strain of M. fermentans. In the present study, one- and two-dimensional electrophoretic analysis demonstrated the expected similarity between these mycoplasmas, but it also demonstrated several distinct protein differences. Nine proteins were identified as strain variable by two-dimensional gel electrophoresis. Also, immunoblot analysis using rabbit antiserum against the type strain of M. fermentans (strain PG 18) documented the occurrence of size heterogeneity in at least one and possibly two other antigens.

Citing Articles

IS1630 of Mycoplasma fermentans, a novel IS30-type insertion element that targets and duplicates inverted repeats of variable length and sequence during insertion.

Calcutt M, Lavrrar J, Wise K J Bacteriol. 1999; 181(24):7597-607.

PMID: 10601219 PMC: 94219. DOI: 10.1128/JB.181.24.7597-7607.1999.

A family of strain-variant surface lipoproteins of Mycoplasma fermentans.

Wise K, Kim M, Theiss P, Lo S Infect Immun. 1993; 61(8):3327-33.

PMID: 8335364 PMC: 281007. DOI: 10.1128/iai.61.8.3327-3333.1993.

Differential protein expression and surface presentation generate high-frequency antigenic variation in Mycoplasma fermentans.

Theiss P, Kim M, Wise K Infect Immun. 1993; 61(12):5123-8.

PMID: 7693594 PMC: 281291. DOI: 10.1128/iai.61.12.5123-5128.1993.

A 48-kilodalton Mycoplasma fermentans membrane protein induces cytokine secretion by human monocytes.

Kostyal D, BUTLER G, Beezhold D Infect Immun. 1994; 62(9):3793-800.

PMID: 7520421 PMC: 303033. DOI: 10.1128/iai.62.9.3793-3800.1994.

Evidence that Lo's mycoplasma (Mycoplasma fermentans incognitus) is not a unique strain among Mycoplasma fermentans strains.

Sasaki T, Sasaki Y, Kita M, Suzuki K, Watanabe H, Honda M J Clin Microbiol. 1992; 30(9):2435-40.

PMID: 1401012 PMC: 265519. DOI: 10.1128/jcm.30.9.2435-2440.1992.

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