Tuning Microenvironments: Induction of Regulatory T Cells by Dendritic Cells

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2008 Sep 19

PMID 18799144

Citations 116

Authors

Yasmine Belkaid

Guillaume Oldenhove

Affiliations

Soon will be listed here.

Abstract

The body requires the generation of regulatory T (Treg) cells to preserve its integrity. Each microenvironment is controlled by a specific set of regulatory elements that have to be finefrly and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes or tumors. Various populations of dendritic cells (DCs) are central to the orchestration of this control. In this review, we will discuss some new findings associating DCs from defined compartments with the induction of antigen-specific Treg cells.

Citing Articles

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Gut redox and microbiome: charting the roadmap to T-cell regulation.

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References

Fitzgerald D, Ciric B, Touil T, Harle H, Grammatikopolou J, Das Sarma J . Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol. 2007; 179(5):3268-75. DOI: 10.4049/jimmunol.179.5.3268. View

Stumhofer J, Silver J, Laurence A, Porrett P, Harris T, Turka L . Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol. 2007; 8(12):1363-71. DOI: 10.1038/ni1537. View

Li C, Corraliza I, Langhorne J . A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect Immun. 1999; 67(9):4435-42. PMC: 96762. DOI: 10.1128/IAI.67.9.4435-4442.1999. View

Awasthi A, Carrier Y, Peron J, Bettelli E, Kamanaka M, Flavell R . A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007; 8(12):1380-9. DOI: 10.1038/ni1541. View

Kastelein R, Hunter C, Cua D . Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol. 2007; 25:221-42. DOI: 10.1146/annurev.immunol.22.012703.104758. View

Carvalho E, Bacellar O, Brownell C, Regis T, Coffman R, Reed S . Restoration of IFN-gamma production and lymphocyte proliferation in visceral leishmaniasis. J Immunol. 1994; 152(12):5949-56. View

Braat H, McGuirk P, Ten Kate F, Huibregtse I, Dunne P, Hommes D . Prevention of experimental colitis by parenteral administration of a pathogen-derived immunomodulatory molecule. Gut. 2006; 56(3):351-7. PMC: 1856816. DOI: 10.1136/gut.2006.099861. View

Bettelli E, Carrier Y, Gao W, Korn T, Strom T, Oukka M . Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006; 441(7090):235-8. DOI: 10.1038/nature04753. View

Cantorna M, Nashold F, Chun T, Hayes C . Vitamin A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway. J Immunol. 1996; 156(8):2674-9. View

10.

Veldhoen M, Hocking R, Atkins C, Locksley R, Stockinger B . TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006; 24(2):179-89. DOI: 10.1016/j.immuni.2006.01.001. View

11.

Gomez-Escobar N, van den Biggelaar A, Maizels R . A member of the TGF-beta receptor gene family in the parasitic nematode Brugia pahangi. Gene. 1997; 199(1-2):101-9. DOI: 10.1016/s0378-1119(97)00353-3. View

12.

Elliott D, Li J, Blum A, Metwali A, Qadir K, Urban Jr J . Exposure to schistosome eggs protects mice from TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2002; 284(3):G385-91. DOI: 10.1152/ajpgi.00049.2002. View

13.

Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S . Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A. 2008; 105(29):10113-8. PMC: 2481354. DOI: 10.1073/pnas.0711106105. View

14.

Fantini M, Becker C, Monteleone G, Pallone F, Galle P, Neurath M . Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol. 2004; 172(9):5149-53. DOI: 10.4049/jimmunol.172.9.5149. View

15.

Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig M, von Boehmer H . Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol. 2005; 6(12):1219-27. DOI: 10.1038/ni1265. View

16.

Vijay-Kumar M, Aitken J, Kumar A, Neish A, Uematsu S, Akira S . Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease. Infect Immun. 2008; 76(3):1276-81. PMC: 2258833. DOI: 10.1128/IAI.01491-07. View

17.

Johansson-Lindbom B, Svensson M, Wurbel M, Malissen B, Marquez G, Agace W . Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med. 2003; 198(6):963-9. PMC: 2194196. DOI: 10.1084/jem.20031244. View

18.

Mucida D, Kutchukhidze N, Erazo A, Russo M, Lafaille J, Curotto de Lafaille M . Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest. 2005; 115(7):1923-33. PMC: 1142115. DOI: 10.1172/JCI24487. View

19.

Rodrigo Mora J, Iwata M, Eksteen B, Song S, Junt T, Senman B . Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006; 314(5802):1157-60. DOI: 10.1126/science.1132742. View

20.

Schambach F, Schupp M, Lazar M, Reiner S . Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol. 2007; 37(9):2396-9. DOI: 10.1002/eji.200737621. View