Lithium Intoxication Related Multiple Temporary Ecg Changes: A Case Report

Overview

Journal Cases J

Specialty General Medicine

Date 2008 Sep 19

PMID 18799007

Citations 11

Authors

Fatih Canan

Ahmet Kaya

Serkan Bulur

Enver Sinan Albayrak

Serkan Ordu

Ahmet Ataoglu

Affiliations

Soon will be listed here.

Abstract

Lithium is a widely used mood stabilizer, which may cause cardiac side effects. In this article, we present the case of a 39-year-old woman who had presented with pre-syncope and developed multiple ECG abnormalities that are caused by lithium intoxication and are disappeared after hemodialysis.

Citing Articles

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Yang B, Sun L, Peng Z, Zhang Q, Lin M, Peng Z Int J Mol Sci. 2024; 25(17).

PMID: 39273255 PMC: 11395654. DOI: 10.3390/ijms25179307.

Lithium and Atypical Antipsychotics: The Possible WNT/β Pathway Target in Glaucoma.

Vallee A, Vallee J, Lecarpentier Y Biomedicines. 2021; 9(5).

PMID: 33925885 PMC: 8146329. DOI: 10.3390/biomedicines9050473.

Lithium: a potential therapeutic strategy in obsessive-compulsive disorder by targeting the canonical WNT/β pathway.

Vallee A, Vallee J, Lecarpentier Y Transl Psychiatry. 2021; 11(1):204.

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Lithium Toxicity in Older Adults: a Systematic Review of Case Reports.

Sun M, Herrmann N, Shulman K Clin Drug Investig. 2017; 38(3):201-209.

PMID: 29189921 DOI: 10.1007/s40261-017-0598-9.

Acute Atrial Fibrillation as an Unusual Form of Cardiotoxicity in Chronic Lithium Overdose.

Kalcik Md M, Ozan Gursoy Md M, Keles Md N, Yesin Md M, Ocal Md L, Eren Md H J Atr Fibrillation. 2016; 6(5):1009.

PMID: 27957048 PMC: 4956136. DOI: 10.4022/jafib.1009.

References

Goldberger Z . Sinoatrial block in lithium toxicity. Am J Psychiatry. 2007; 164(5):831-2. DOI: 10.1176/ajp.2007.164.5.831. View

Griswold K, Pessar L . Management of bipolar disorder. Am Fam Physician. 2000; 62(6):1343-53, 1357-8. View

Mateer J, Clark M . Lithium toxicity with rarely reported ECG manifestations. Ann Emerg Med. 1982; 11(4):208-11. DOI: 10.1016/s0196-0644(82)80500-3. View

Waring W . Management of lithium toxicity. Toxicol Rev. 2007; 25(4):221-30. DOI: 10.2165/00139709-200625040-00003. View

Mitchell J, Mackenzie T . Cardiac effects of lithium therapy in man: a review. J Clin Psychiatry. 1982; 43(2):47-51. View

Waring W . Delayed cardiotoxicity in chronic lithium poisoning: discrepancy between serum lithium concentrations and clinical status. Basic Clin Pharmacol Toxicol. 2007; 100(5):353-5. DOI: 10.1111/j.1742-7843.2007.00054.x. View

Mamiya K, Sadanaga T, Sekita A, Nabeyama Y, Yao H, Yukawa E . Lithium concentration correlates with QTc in patients with psychosis. J Electrocardiol. 2005; 38(2):148-51. DOI: 10.1016/j.jelectrocard.2004.10.004. View

Singer I, Rotenberg D . Mechanisms of lithium action. N Engl J Med. 1973; 289(5):254-60. DOI: 10.1056/NEJM197308022890508. View

RICCIONI N, Roni P, Bartolomei C . Lithium-induced sinus node dysfunction. Acta Cardiol. 1983; 38(2):133-8. View

10.

Rosenqvist M, Bergfeldt L, Aili H, Mathe A . Sinus node dysfunction during long-term lithium treatment. Br Heart J. 1993; 70(4):371-5. PMC: 1025335. DOI: 10.1136/hrt.70.4.371. View

11.

Fann W, Davis J, Janowsky D, CAVANAUGH J, Kaufmann J, Griffith J . Effects of lithium on adrenergic function in man. Clin Pharmacol Ther. 1972; 13(1):71-7. DOI: 10.1002/cpt197213171. View

12.

Waring W, Laing W, Good A, Bateman D . Pattern of lithium exposure predicts poisoning severity: evaluation of referrals to a regional poisons unit. QJM. 2007; 100(5):271-6. DOI: 10.1093/qjmed/hcm017. View