Rheumatoid Arthritis Susceptibility Loci at Chromosomes 10p15, 12q13 and 22q13

Overview

Journal Nat Genet

Specialty Genetics

Date 2008 Sep 17

PMID 18794857

Citations 71

Authors

Anne Barton

Wendy Thomson

Xiayi Ke

Steve Eyre

Anne Hinks

John Bowes

Darren Plant

Laura J Gibbons

Anthony G Wilson

Deborah E Bax

Ann W Morgan

Paul Emery

Sophia Steer

Lynne Hocking

David M Reid

Paul Wordsworth

Pille Harrison

Jane Worthington

Affiliations

Soon will be listed here.

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

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