Uremic Lung: New Insights into a Forgotten Condition

Overview

Journal Kidney Int

Publisher Elsevier

Specialty Nephrology

Date 2008 Sep 17

PMID 18794816

Citations 29

Authors

Paul J Scheel

Manchang Liu

Hamid Rabb

Affiliations

Soon will be listed here.

Abstract

The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.

Citing Articles

The Neglected Price of Pediatric Acute Kidney Injury: Non-renal Implications.

Pande C, Smith M, Soranno D, Gist K, Fuhrman D, Dolan K Front Pediatr. 2022; 10:893993.

PMID: 35844733 PMC: 9279899. DOI: 10.3389/fped.2022.893993.

Two to Tango: Kidney-Lung Interaction in Acute Kidney Injury and Acute Respiratory Distress Syndrome.

Alge J, Dolan K, Angelo J, Thadani S, Virk M, Arikan A Front Pediatr. 2021; 9:744110.

PMID: 34733809 PMC: 8559585. DOI: 10.3389/fped.2021.744110.

Acute kidney injury.

Kellum J, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders H Nat Rev Dis Primers. 2021; 7(1):52.

PMID: 34267223 DOI: 10.1038/s41572-021-00284-z.

[Interactions between lung and kidney in the critically ill].

Klein S, Husain-Syed F, Karagiannidis C, Lehner G, Singbartl K, Joannidis M Med Klin Intensivmed Notfmed. 2018; 113(6):448-455.

PMID: 30094502 DOI: 10.1007/s00063-018-0472-4.

The Microbiome and Acute Kidney Injury.

Rabb H, Pluznick J, Noel S Nephron. 2018; 140(2):120-123.

PMID: 29961049 PMC: 6292672. DOI: 10.1159/000490392.