Mammographic Density, Lobular Involution, and Risk of Breast Cancer

Overview

Journal Br J Cancer

Specialty Oncology

Date 2008 Sep 11

PMID 18781174

Citations 64

Authors

O M Ginsburg

L J Martin

N F Boyd

Affiliations

Soon will be listed here.

Abstract

In this review, we propose that age-related changes in mammographic density and breast tissue involution are closely related phenomena, and consider their potential relevance to the aetiology of breast cancer. We propose that the reduction in mammographic density that occurs with increasing age, parity and menopause reflects the involution of breast tissue. We further propose that age-related changes in both mammographic density and breast tissue composition are observable and measurable phenomena that resemble Pike's theoretical construct of 'breast tissue ageing'. Extensive mammographic density and delayed breast involution are both associated with an increased risk of breast cancer and are consistent with the hypothesis of the Pike model that cumulative exposure of breast tissue to hormones and growth factors that stimulate cell division, as well as the accumulation of genetic damage in breast cells, are major determinants of breast cancer incidence.

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References

Ziv E, Tice J, Smith-Bindman R, Shepherd J, Cummings S, Kerlikowske K . Mammographic density and estrogen receptor status of breast cancer. Cancer Epidemiol Biomarkers Prev. 2004; 13(12):2090-5. View

Vachon C, Sellers T, Carlson E, Cunningham J, Hilker C, Smalley R . Strong evidence of a genetic determinant for mammographic density, a major risk factor for breast cancer. Cancer Res. 2007; 67(17):8412-8. DOI: 10.1158/0008-5472.CAN-07-1076. View

Nelson C, Bissell M . Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2006; 22:287-309. PMC: 2933192. DOI: 10.1146/annurev.cellbio.22.010305.104315. View

Wolfe J . Risk for breast cancer development determined by mammographic parenchymal pattern. Cancer. 1976; 37(5):2486-92. DOI: 10.1002/1097-0142(197605)37:5<2486::aid-cncr2820370542>3.0.co;2-8. View

Henson D, Tarone R . Involution and the etiology of breast cancer. Cancer. 1994; 74(1 Suppl):424-9. DOI: 10.1002/cncr.2820741330. View

Johns P, Yaffe M . X-ray characterisation of normal and neoplastic breast tissues. Phys Med Biol. 1987; 32(6):675-95. DOI: 10.1088/0031-9155/32/6/002. View

Boyd N, Guo H, Martin L, Sun L, Stone J, Fishell E . Mammographic density and the risk and detection of breast cancer. N Engl J Med. 2007; 356(3):227-36. DOI: 10.1056/NEJMoa062790. View

Warner E, Lockwood G, Tritchler D, Boyd N . The risk of breast cancer associated with mammographic parenchymal patterns: a meta-analysis of the published literature to examine the effect of method of classification. Cancer Detect Prev. 1992; 16(1):67-72. View

Dupont W, Page D . Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med. 1985; 312(3):146-51. DOI: 10.1056/NEJM198501173120303. View

10.

Wolfe J . Breast patterns as an index of risk for developing breast cancer. AJR Am J Roentgenol. 1976; 126(6):1130-7. DOI: 10.2214/ajr.126.6.1130. View

11.

Pike M, Krailo M, Henderson B, Casagrande J, Hoel D . 'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer. Nature. 1983; 303(5920):767-70. DOI: 10.1038/303767a0. View

12.

Boyd N, Jensen H, Cooke G, Han H . Relationship between mammographic and histological risk factors for breast cancer. J Natl Cancer Inst. 1992; 84(15):1170-9. DOI: 10.1093/jnci/84.15.1170. View

13.

Boyd N, Rommens J, Vogt K, Lee V, Hopper J, Yaffe M . Mammographic breast density as an intermediate phenotype for breast cancer. Lancet Oncol. 2005; 6(10):798-808. DOI: 10.1016/S1470-2045(05)70390-9. View

14.

Milanese T, Hartmann L, Sellers T, Frost M, Vierkant R, Maloney S . Age-related lobular involution and risk of breast cancer. J Natl Cancer Inst. 2006; 98(22):1600-7. DOI: 10.1093/jnci/djj439. View

15.

Kerlikowske K, Ichikawa L, Miglioretti D, Buist D, Vacek P, Smith-Bindman R . Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk. J Natl Cancer Inst. 2007; 99(5):386-95. DOI: 10.1093/jnci/djk066. View

16.

Rosner B, Colditz G . Nurses' health study: log-incidence mathematical model of breast cancer incidence. J Natl Cancer Inst. 1996; 88(6):359-64. DOI: 10.1093/jnci/88.6.359. View

17.

Boyd N, Martin L, Stone J, Little L, Minkin S, Yaffe M . A longitudinal study of the effects of menopause on mammographic features. Cancer Epidemiol Biomarkers Prev. 2002; 11(10 Pt 1):1048-53. View

18.

Martin L, Boyd N . Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence. Breast Cancer Res. 2008; 10(1):201. PMC: 2374950. DOI: 10.1186/bcr1831. View

19.

Maskarinec G, Pagano I, Lurie G, Kolonel L . A longitudinal investigation of mammographic density: the multiethnic cohort. Cancer Epidemiol Biomarkers Prev. 2006; 15(4):732-9. DOI: 10.1158/1055-9965.EPI-05-0798. View

20.

Bartow S, Pathak D, Black W, Key C, Teaf S . Prevalence of benign, atypical, and malignant breast lesions in populations at different risk for breast cancer. A forensic autopsy study. Cancer. 1987; 60(11):2751-60. DOI: 10.1002/1097-0142(19871201)60:11<2751::aid-cncr2820601127>3.0.co;2-m. View