Diffusion Tensor Analysis of Corpus Callosum in Progressive Supranuclear Palsy

Overview

Journal Neuroradiology

Specialties Neurology
Radiology

Date 2008 Sep 10

PMID 18779957

Citations 20

Authors

Shoichi Ito

Takahiro Makino

Wakako Shirai

Takamichi Hattori

Affiliations

Soon will be listed here.

Abstract

Introduction: Progressive supranuclear palsy (PSP) is a neurodegenerative disease featuring parkinsonism, supranuclear ophthalmoplegia, dysphagia, and frontal lobe dysfunction. The corpus callosum which consists of many commissure fibers probably reflects cerebral cortical function. Several previous reports showed atrophy or diffusion abnormalities of anterior corpus callosum in PSP patients, but partitioning method used in these studies was based on data obtained in nonhuman primates. In this study, we performed a diffusion tensor analysis using a new partitioning method for the human corpus callosum.

Methods: Seven consecutive patients with PSP were compared with 29 age-matched patients with Parkinson's Disease (PD) and 19 age-matched healthy control subjects. All subjects underwent diffusion tensor magnetic resonance imaging, and the corpus callosum was partitioned into five areas on the mid-sagittal plane according to a recently established topography of human corpus callosum (CC1-prefrontal area, CC2-premotor and supplementary motor area, CC3-motor area, CC4-sensory area, CC5-parietal, temporal, and occipital area). Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in each area and differences between groups were analyzed.

Results: In the PSP group, FA values were significantly decreased in CC1 and CC2, and ADC values were significantly increased in CC1 and CC2. Receiver operating characteristic analysis showed excellent reliability of FA and ADC analyses of CC1 for differentiating PSP from PD.

Conclusion: The anterior corpus callosum corresponding to the prefrontal, premotor, and supplementary motor cortices is affected in PSP patients. This analysis can be an additional test for further confirmation of the diagnosis of PSP.

Citing Articles

Recent advances in using diffusion tensor imaging to study white matter alterations in Parkinson's disease: A mini review.

Shih Y, Tseng W, Montaser-Kouhsari L Front Aging Neurosci. 2023; 14:1018017.

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A longitudinal fixel-based analysis of white matter alterations in patients with Parkinson's disease.

Rau Y, Wang S, Tournier J, Lin S, Lu C, Weng Y Neuroimage Clin. 2019; 24():102098.

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Development of a transcallosal tractography template and its application to dementia.

Archer D, Coombes S, McFarland N, DeKosky S, Vaillancourt D Neuroimage. 2019; 200:302-312.

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Track density imaging in progressive supranuclear palsy: A pilot study.

Nigro S, Bianco M, Arabia G, Morelli M, Nistico R, Novellino F Hum Brain Mapp. 2018; 40(6):1729-1737.

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Role of Corpus Callosum Volumetry in Differentiating the Subtypes of Progressive Supranuclear Palsy and Early Parkinson's Disease.

Lenka A, Pasha S, Mangalore S, George L, Jhunjhunwala K, Bagepally B Mov Disord Clin Pract. 2018; 4(4):552-558.

PMID: 30363434 PMC: 6174399. DOI: 10.1002/mdc3.12473.

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