Labeling of Polymer Nanostructures for Medical Imaging: Importance of Crosslinking Extent, Spacer Length, and Charge Density

Overview

Journal Macromolecules

Date 2008 Sep 10

PMID 18779874

Citations 19

Authors

Jinqi Xu

Guorong Sun

Raffaella Rossin

Aviv Hagooly

Zicheng Li

Ken-Ichi Fukukawa

Benjamin W Messmore

Dennis A Moore

Michael J Welch

Craig J Hawker

Karen L Wooley

Affiliations

Soon will be listed here.

Abstract

Radiolabeling studies were employed to investigate the influence of structure on the efficiency of surface functionalization for poly(acrylic acid)-coated shell crosslinked nanoparticles (SCKs) with two types of amine-terminated DOTA chelators. An intricate interplay between the chemical and physical properties of both the DOTA derivative and the SCK nanostructures was revealed, demonstrating the importance of structural control.

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