Association of Polymorphisms in the Interleukin 23 Receptor Gene with Osteonecrosis of Femoral Head in Korean Population

Overview

Journal Exp Mol Med

Specialties Biochemistry
Molecular Biology

Date 2008 Sep 10

PMID 18779654

Citations 13

Authors

Tae-Ho Kim

Jung Min Hong

Bermseok Oh

Yoon Shin Cho

Jong-Young Lee

Hyung-Lae Kim

Jong-Eun Lee

Mi-Hyun Ha

Eui Kyun Park

Shin-Yoon Kim

Affiliations

Soon will be listed here.

Abstract

Osteonecrosis of the femoral head (ONFH) is known as death of the cellular portion of the femoral head due to an interruption in the vascular supply. The underlying pathophysiology regarding bone cell death remains uncertain. Recently, several studies have shown that autoimmune disorders were related to the development of osteonecrosis. This study investigated the genetic effects of Interleukin 23 receptor (IL23R) polymorphisms regarding the risk of ONFH. Ten SNPs were selected and genotyped in 443 ONFH patients and 273 control subjects in order to perform the genetic association analysis. It was found that polymorphisms of the IL23R gene (rs4655686, rs1569922 and rs7539625) were significantly associated with an increased risk of ONFH (P values; 0.0198-0.0447, OR; 1.30-1.49). Particularly, a stratified analysis based on etiology (alcohol, steroid or idiopathic) showed that the associations between these polymorphisms and ONFH were most significant in idiopathic ONFH patients (P values; 0.0001-0.0150, OR; 1.45-2.17). These results suggest that IL23R polymorphisms may play an important role in the development of ONFH.

Citing Articles

Identification of Inflammation-Related Genes and Exploration of Regulatory Mechanisms in Patients with Osteonecrosis of the Femoral Head.

Li T, Huang C, Ma J, Ding R, Zhang Q, Wang W Biomed Res Int. 2022; 2022:4501186.

PMID: 36193326 PMC: 9526608. DOI: 10.1155/2022/4501186.

Association of Specific Genetic Polymorphisms with Atraumatic Osteonecrosis of the Femoral Head: A Narrative Review.

Kumar P, Rathod P, Aggarwal S, Patel S, Kumar V, Jindal K Indian J Orthop. 2022; 56(5):771-784.

PMID: 35547337 PMC: 9043172. DOI: 10.1007/s43465-021-00583-3.

Osteoimmunology and osteonecrosis of the femoral head.

Ma M, Tan Z, Li W, Zhang H, Liu Y, Yue C Bone Joint Res. 2022; 11(1):26-28.

PMID: 35045723 PMC: 8801166. DOI: 10.1302/2046-3758.111.BJR-2021-0467.R1.

Osteonecrosis of the femoral head: genetic basis.

Wang T, Azeddine B, Mah W, Harvey E, Rosenblatt D, Seguin C Int Orthop. 2018; 43(3):519-530.

PMID: 30328481 DOI: 10.1007/s00264-018-4172-8.

Combination analysis of NOS3, ABCB1 and IL23R polymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males.

Wang Y, Yang X, Shi J, Zhao Y, Pan L, Zhou J Oncotarget. 2017; 8(20):33770-33778.

PMID: 28422712 PMC: 5464910. DOI: 10.18632/oncotarget.16809.

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