Mucosal Cytokine Network in Inflammatory Bowel Disease

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2008 Sep 9

PMID 18777592

Citations 45

Authors

Akira Andoh

Yuhki Yagi

Makoto Shioya

Atsushi Nishida

Tomoyuki Tsujikawa

Yoshihide Fujiyama

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved. The chronic inflammatory process leads to disruption of the epithelial barrier, and the formation of epithelial ulceration. This permits easy access for the luminal microbiota and dietary antigens to cells resident in the lamina propria, and stimulates further pathological immune cell responses. Cytokines are essential mediators of the interactions between activated immune cells and non-immune cells, including epithelial and mesenchymal cells. The clinical efficacy of targeting TNF-alpha clearly indicates that cytokines are the therapeutic targets in IBD patients. In this manuscript, we focus on the biological activities of recently-reported cytokines [Interleukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-alpha in the pathophysiology of IBD.

Citing Articles

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Interleukin (IL)-23, IL-31, and IL-33 Play a Role in the Course of Autoimmune Endocrine Diseases.

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The anti-inflammatory and protective role of interleukin-38 in inflammatory bowel disease.

Ohno M, Imai T, Chatani M, Nishida A, Inatomi O, Kawahara M J Clin Biochem Nutr. 2022; 70(1):64-71.

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