» Articles » PMID: 18772374

Crosspresentation by Nonhematopoietic and Direct Presentation by Hematopoietic Cells Induce Central Tolerance to Myelin Basic Protein

Overview
Specialty Science
Date 2008 Sep 6
PMID 18772374
Citations 15
Authors
Affiliations
Soon will be listed here.
Abstract

Central tolerance plays a critical role in eliminating self-reactive T cells specific for peripheral antigens. Here we show that central tolerance of MHC class I-restricted T cells specific for classic myelin basic protein (MBP), a component of the myelin sheath, is mediated by both bone marrow (BM)-derived and nonBM-derived cells. Unexpectedly, BM-derived cells induce tolerance directly by using classic MBP that they synthesize, whereas nonBM-derived cells mediate tolerance by crosspresenting classic MBP acquired from an exogenous source. Thus, tolerance to tissue-specific antigens can involve multiple cell types and mechanisms in the thymus, which may account for the limited spectrum of autoimmune syndromes observed when expression of tissue-specific antigens is impaired only in thymic epithelial cells.

Citing Articles

The contribution of thymic tolerance to central nervous system autoimmunity.

Alberti P, Handel A Semin Immunopathol. 2020; 43(1):135-157.

PMID: 33108502 PMC: 7925481. DOI: 10.1007/s00281-020-00822-z.


Proteolytic dynamics of human 20S thymoproteasome.

Kuckelkorn U, Stubler S, Textoris-Taube K, Kilian C, Niewienda A, Henklein P J Biol Chem. 2019; 294(19):7740-7754.

PMID: 30914481 PMC: 6514615. DOI: 10.1074/jbc.RA118.007347.


Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.

Yap J, Wirasinha R, Chan A, Howard D, Goodnow C, Daley S Immunology. 2018; 154(3):522-532.

PMID: 29411880 PMC: 6002238. DOI: 10.1111/imm.12904.


The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.

Cruz F, Colbert J, Merino E, Kriegsman B, Rock K Annu Rev Immunol. 2017; 35():149-176.

PMID: 28125356 PMC: 5508990. DOI: 10.1146/annurev-immunol-041015-055254.


Current understanding on the role of standard and immunoproteasomes in inflammatory/immunological pathways of multiple sclerosis.

Bellavista E, Santoro A, Galimberti D, Comi C, Luciani F, Mishto M Autoimmune Dis. 2014; 2014:739705.

PMID: 24523959 PMC: 3910067. DOI: 10.1155/2014/739705.


References
1.
Zerrahn J, Volkmann A, Coles M, HELD W, Lemonnier F, Raulet D . Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells. Proc Natl Acad Sci U S A. 1999; 96(20):11470-5. PMC: 18057. DOI: 10.1073/pnas.96.20.11470. View

2.
Feng J, Hu Y, Xie L, Colwell C, Shao X, Sun X . Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity. 2006; 24(6):717-727. DOI: 10.1016/j.immuni.2006.04.007. View

3.
Zheng X, Yin L, Liu Y, Zheng P . Expression of tissue-specific autoantigens in the hematopoietic cells leads to activation-induced cell death of autoreactive T cells in the secondary lymphoid organs. Eur J Immunol. 2004; 34(11):3126-34. DOI: 10.1002/eji.200425177. View

4.
Huseby E, Sather B, Huseby P, Goverman J . Age-dependent T cell tolerance and autoimmunity to myelin basic protein. Immunity. 2001; 14(4):471-81. DOI: 10.1016/s1074-7613(01)00127-3. View

5.
Perchellet A, Stromnes I, Pang J, Goverman J . CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'. Nat Immunol. 2004; 5(6):606-14. DOI: 10.1038/ni1073. View