Mechanisms of Induction of Adenosine Receptor Genes and Its Functional Significance

Overview

Journal J Cell Physiol

Specialties Cell Biology
Physiology

Date 2008 Sep 4

PMID 18767039

Citations 37

Authors

Cynthia St Hilaire

Shannon H Carroll

Hongjie Chen

Katya Ravid

Affiliations

Soon will be listed here.

Abstract

Adenosine is a metabolite generated and released from cells, particularly under injury or stress. It elicits protective or damaging responses via signaling through the adenosine receptors, including the adenylyl cyclase inhibitory A(1) and A(3), and the adenylyl cyclase stimulatory A(2A) and A(2B). Multiple adenosine receptor types, including stimulatory and inhibitory, can be found in the same cell, suggesting that a careful balance of adenosine receptor expression in a particular cell is necessary for a specific adenosine-induced response. This balance could be controlled by differential expression of the adenosine receptor genes under different stimuli. Here, we have reviewed an array of studies that have characterized basal or induced expression of the adenosine receptors and common as well as distinct mechanisms of effect, in hopes that ongoing studies on this topic will further elucidate detailed mechanisms of adenosine receptor regulation, leading to potential therapeutic applications.

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