No High-risk HPV Detected in SCC of the Oral Tongue in the Absolute Absence of Tobacco and Alcohol--a Case Study of Seven Patients

Overview

Journal Oral Maxillofac Surg

Specialties Dentistry
General Surgery

Date 2008 Sep 3

PMID 18762997

Citations 4

Authors

T J H Siebers

M A W Merkx

P J Slootweg

W J G Melchers

P van Cleef

P C M de Wilde

Affiliations

Soon will be listed here.

Abstract

Introduction: In recent years, there has been an increase in the number of patients with squamous cell carcinoma (SCC) of the mobile tongue in the absence of tobacco and alcohol. The literature suggests that human papilloma virus (HPV) may be involved in the development of SCC of the head and neck, especially in non-smoking and non-drinking patients. In the oral cavity, however, the presence of the HPV genome has been reported with various percentages. This may be due to misclassification of the oropharyngeal tongue as oral cavity subsite and the use of various detection methods.

Materials And Methods: Therefore, we evaluated the role of HPV in seven consecutive non-smoking and non-drinking patients (2003-2006) with a SCC located at the oral, mobile tongue using in situ hybridization and SPF(10)Line Blot 25 polymerase chain reaction assays.

Results: No HPV was detected in these specimens. To further determine whether a relationship exists between HPV and SCC in the absence of tobacco and alcohol, subsequent studies at specific locations are necessary.

Citing Articles

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A rapidly growing human papillomavirus-positive oral tongue squamous cell carcinoma in a 21-year old female: A case report.

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Immunohistochemical staining of Langerhans cells in HPV-positive and HPV-negative cases of oral squamous cells carcinoma.

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