Large-conductance Calcium-dependent Potassium Channels Prevent Dendritic Excitability in Neocortical Pyramidal Neurons

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2008 Sep 3

PMID 18762971

Citations 20

Authors

Narimane Benhassine

Thomas Berger

Affiliations

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Abstract

Large-conductance calcium-dependent potassium channels (BK channels) are homogeneously distributed along the somatodendritic axis of layer 5 pyramidal neurons of the rat somatosensory cortex. The relevance of this conductance for dendritic calcium electrogenesis was studied in acute brain slices using somatodendritic patch clamp recordings and calcium imaging. BK channel activation reduces the occurrence of dendritic calcium spikes. This is reflected in an increased critical frequency of somatic spikes necessary to activate the distal initiation zone. Whilst BK channels repolarise the somatic spike, they dampen it only in the distal dendrite. Their activation reduces dendritic calcium influx via glutamate receptors. Furthermore, they prevent dendritic calcium electrogenesis and subsequent somatic burst discharges. However, the time window for coincident somatic action potential and dendritic input to elicit dendritic calcium events is not influenced by BK channels. Thus, BK channel activation in layer 5 pyramidal neurons affects cellular excitability primarily by establishing a high threshold at the distal action potential initiation zone.

Citing Articles

Large conductance voltage-and calcium-activated K (BK) channel in health and disease.

Echeverria F, Gonzalez-Sanabria N, Alvarado-Sanchez R, Fernandez M, Castillo K, Latorre R Front Pharmacol. 2024; 15:1373507.

PMID: 38584598 PMC: 10995336. DOI: 10.3389/fphar.2024.1373507.

Ca- and Voltage-Activated K (BK) Channels in the Nervous System: One Gene, a Myriad of Physiological Functions.

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Paradoxical Excitatory Impact of SK Channels on Dendritic Excitability.

Bock T, Honnuraiah S, Stuart G J Neurosci. 2019; 39(40):7826-7839.

PMID: 31420457 PMC: 6774406. DOI: 10.1523/JNEUROSCI.0105-19.2019.

Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing.

Irie T, Trussell L Neuron. 2017; 96(4):856-870.e4.

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The Impact of BK Channels on Cellular Excitability Depends on their Subcellular Location.

Bock T, Stuart G Front Cell Neurosci. 2016; 10:206.

PMID: 27630543 PMC: 5006691. DOI: 10.3389/fncel.2016.00206.

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