Toona Sinensis Roem Tender Leaf Extract Inhibits SARS Coronavirus Replication

Overview

Journal J Ethnopharmacol

Date 2008 Sep 3

PMID 18762235

Citations 67

Authors

Chung-Jen Chen

Martin Michaelis

Hseng-Kuang Hsu

Chin-Chuan Tsai

Kunder D Yang

Yang-Chang Wu

Jindrich Cinatl Jr

Hans Wilhelm Doerr

Affiliations

Soon will be listed here.

Abstract

Aim Of The Study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV.

Materials And Methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro.

Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12 approximately 17.

Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.

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References

Yang Y, Hsu H, Hwang J, Hong S . Enhancement of glucose uptake in 3T3-L1 adipocytes by Toona sinensis leaf extract. Kaohsiung J Med Sci. 2003; 19(7):327-33. DOI: 10.1016/S1607-551X(09)70433-4. View

Wang P, Tsai M, Hsu C, Wang C, Hsu H, Weng C . Toona sinensis Roem (Meliaceae) leaf extract alleviates hyperglycemia via altering adipose glucose transporter 4. Food Chem Toxicol. 2008; 46(7):2554-60. DOI: 10.1016/j.fct.2008.04.011. View

Yang H, Chang W, Chia Y, Huang C, Lu F, Hsu H . Toona sinensis extracts induces apoptosis via reactive oxygen species in human premyelocytic leukemia cells. Food Chem Toxicol. 2006; 44(12):1978-88. DOI: 10.1016/j.fct.2006.06.027. View

Michaelis M, Kohler N, Reinisch A, Eikel D, Gravemann U, Doerr H . Increased human cytomegalovirus replication in fibroblasts after treatment with therapeutical plasma concentrations of valproic acid. Biochem Pharmacol. 2004; 68(3):531-8. DOI: 10.1016/j.bcp.2004.04.013. View

Chang H, Hung W, Huang M, Hsu H . Extract from the leaves of Toona sinensis roemor exerts potent antiproliferative effect on human lung cancer cells. Am J Chin Med. 2002; 30(2-3):307-14. DOI: 10.1142/S0192415X02000223. View

Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr H . Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet. 2003; 361(9374):2045-6. PMC: 7112442. DOI: 10.1016/s0140-6736(03)13615-x. View

Hsieh P, Chang F, Chang C, Cheng P, Chiang L, Zeng F . 2-Substituted benzoxazinone analogues as anti-human coronavirus (anti-HCoV) and ICAM-1 expression inhibition agents. Bioorg Med Chem Lett. 2004; 14(18):4751-4. PMC: 7126427. DOI: 10.1016/j.bmcl.2004.06.083. View

Cinatl Jr J, Michaelis M, Hoever G, Preiser W, Doerr H . Development of antiviral therapy for severe acute respiratory syndrome. Antiviral Res. 2005; 66(2-3):81-97. PMC: 7132397. DOI: 10.1016/j.antiviral.2005.03.002. View

Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr H . Treatment of SARS with human interferons. Lancet. 2003; 362(9380):293-4. PMC: 7112413. DOI: 10.1016/s0140-6736(03)13973-6. View

10.

Mosmann T . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2):55-63. DOI: 10.1016/0022-1759(83)90303-4. View

11.

Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G . Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol. 2004; 78(20):11334-9. PMC: 521800. DOI: 10.1128/JVI.78.20.11334-11339.2004. View

12.

Drosten C, Gunther S, Preiser W, van der Werf S, Brodt H, Becker S . Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med. 2003; 348(20):1967-76. DOI: 10.1056/NEJMoa030747. View