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P53 Strikes MTORC1 by Employing Sestrins

Overview
Journal Cell Metab
Publisher Cell Press
Date 2008 Sep 3
PMID 18762019
Citations 28
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Abstract

The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestrin2.

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