Individual Differences in Acute Alcohol Impairment of Inhibitory Control Predict Ad Libitum Alcohol Consumption

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2008 Sep 2

PMID 18758758

Citations 80

Authors

Jessica Weafer

Mark T Fillmore

Affiliations

Soon will be listed here.

Abstract

Rationale: Research has begun to examine how acute cognitive impairment from alcohol could contribute to alcohol abuse. Specifically, alcohol-induced impairment of inhibitory control could compromise the drinker's ability to stop the self-administration of alcohol, increasing the risk of binge drinking.

Objective: The present study was designed to test this hypothesis by examining the relation between acute alcohol impairment of inhibitory control and alcohol consumption during a single drinking episode.

Materials And Methods: Twenty-six healthy adults performed a cued go/no-go task that measured inhibitory control. The study tested the degree to which their inhibitory control was impaired by a moderate dose of alcohol (0.65 g/kg) versus a placebo and the extent to which individual differences in this impairment predicted levels of alcohol consumption as assessed by ad lib drinking in the laboratory.

Results: In accord with the hypothesis, greater impairment of inhibitory control from alcohol was associated with increased ad lib consumption.

Conclusion: Acute impairment of inhibitory control might be an important cognitive effect that contributes to abuse in addition to the positive rewarding effects of the drug.

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