Serum Anti-Müllerian Hormone and Inhibin B Levels at Ovulation Triggering Day Can Predict the Number of Immature Oocytes Retrieved in in Vitro Fertilization Cycles

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2008 Aug 30

PMID 18756053

Citations 8

Authors

Byung Chul Jee

Seung Yup Ku

Chang Suk Suh

Ki Chul Kim

Won Don Lee

Seok Hyun Kim

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate whether serum levels of anti-Müllerian hormone (AMH) and inhibin B at ovulation triggering day correlate with the number of immature oocytes obtained from stimulated in vitro fertilization (IVF) cycles. Fifty-nine consecutive cycles of ovarian hyperstimulation and IVF were selected from 45 women who had tubal (n=18) or unexplained infertility (n=27) and obtained at least one oocyte. Serum levels of AMH and inhibin B at ovulation triggering day were measured by enzyme-linked immunosorbent assay (ELISA). Univariate analysis and multiple regressions revealed that serum AMH or inhibin B levels were significantly correlated with immature oocyte count and the correlation coefficients were higher compared to the mature oocyte count. Serum AMH and inhibin B levels on triggering day seems to be more closely related with the immature oocyte count and thus could be good predictors to determine the immature oocyte count in IVF cycle.

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References

Penarrubia J, Fabregues F, Manau D, Creus M, Casals G, Casamitjana R . Basal and stimulation day 5 anti-Mullerian hormone serum concentrations as predictors of ovarian response and pregnancy in assisted reproductive technology cycles stimulated with gonadotropin-releasing hormone agonist--gonadotropin treatment. Hum Reprod. 2005; 20(4):915-22. DOI: 10.1093/humrep/deh718. View

Fried G, Remaeus K, Harlin J, Krog E, Csemiczky G, Aanesen A . Inhibin B predicts oocyte number and the ratio IGF-I/IGFBP-1 may indicate oocyte quality during ovarian hyperstimulation for in vitro fertilization. J Assist Reprod Genet. 2003; 20(5):167-76. PMC: 3455298. DOI: 10.1023/a:1023656225053. View

Creus M, Penarrubia J, Fabregues F, Vidal E, Carmona F, Casamitjana R . Day 3 serum inhibin B and FSH and age as predictors of assisted reproduction treatment outcome. Hum Reprod. 2000; 15(11):2341-6. DOI: 10.1093/humrep/15.11.2341. View

Weenen C, Laven J, von Bergh A, Cranfield M, Groome N, Visser J . Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. Mol Hum Reprod. 2004; 10(2):77-83. DOI: 10.1093/molehr/gah015. View

van Rooij I, Broekmans F, Te Velde E, Fauser B, Bancsi L, de Jong F . Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum Reprod. 2002; 17(12):3065-71. DOI: 10.1093/humrep/17.12.3065. View

Muttukrishna S, McGarrigle H, Wakim R, Khadum I, Ranieri D, Serhal P . Antral follicle count, anti-mullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology?. BJOG. 2005; 112(10):1384-90. DOI: 10.1111/j.1471-0528.2005.00670.x. View

Eldar-Geva T, Margalioth E, Gal M, Ben-Chetrit A, Algur N, Zylber-Haran E . Serum anti-Mullerian hormone levels during controlled ovarian hyperstimulation in women with polycystic ovaries with and without hyperandrogenism. Hum Reprod. 2005; 20(7):1814-9. DOI: 10.1093/humrep/deh873. View

Feyereisen E, Lozano D, Taieb J, Hesters L, Frydman R, Fanchin R . Anti-Müllerian hormone: clinical insights into a promising biomarker of ovarian follicular status. Reprod Biomed Online. 2006; 12(6):695-703. DOI: 10.1016/s1472-6483(10)61081-4. View

Nogueira D, Friedler S, Schachter M, Raziel A, Ron-El R, Smitz J . Oocyte maturity and preimplantation development in relation to follicle diameter in gonadotropin-releasing hormone agonist or antagonist treatments. Fertil Steril. 2006; 85(3):578-83. DOI: 10.1016/j.fertnstert.2005.08.033. View

10.

Urbancsek J, Hauzman E, Klinga K, Rabe T, Papp Z, Strowitzki T . Use of serum inhibin B levels at the start of ovarian stimulation and at oocyte pickup in the prediction of assisted reproduction treatment outcome. Fertil Steril. 2005; 83(2):341-8. DOI: 10.1016/j.fertnstert.2004.06.065. View

11.

Seifer D, MacLaughlin D, Christian B, Feng B, Shelden R . Early follicular serum müllerian-inhibiting substance levels are associated with ovarian response during assisted reproductive technology cycles. Fertil Steril. 2002; 77(3):468-71. DOI: 10.1016/s0015-0282(01)03201-0. View

12.

Fanchin R, Louafi N, Lozano D, Frydman N, Frydman R, Taieb J . Per-follicle measurements indicate that anti-müllerian hormone secretion is modulated by the extent of follicular development and luteinization and may reflect qualitatively the ovarian follicular status. Fertil Steril. 2005; 84(1):167-73. DOI: 10.1016/j.fertnstert.2005.01.115. View

13.

Fanchin R, Schonauer L, Righini C, Guibourdenche J, Frydman R, Taieb J . Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod. 2003; 18(2):323-7. DOI: 10.1093/humrep/deg042. View

14.

Freour T, Mirallie S, Bach-Ngohou K, Denis M, Barriere P, Masson D . Measurement of serum anti-Müllerian hormone by Beckman Coulter ELISA and DSL ELISA: comparison and relevance in assisted reproduction technology (ART). Clin Chim Acta. 2006; 375(1-2):162-4. DOI: 10.1016/j.cca.2006.06.013. View

15.

Lockwood G, Muttukrishna S, Ledger W . Inhibins and activins in human ovulation, conception and pregnancy. Hum Reprod Update. 1998; 4(3):284-95. DOI: 10.1093/humupd/4.3.284. View

16.

Fanchin R, Schonauer L, Righini C, Frydman N, Frydman R, Taieb J . Serum anti-Müllerian hormone dynamics during controlled ovarian hyperstimulation. Hum Reprod. 2003; 18(2):328-32. DOI: 10.1093/humrep/deg043. View

17.

Fanchin R, Taieb J, Lozano D, Ducot B, Frydman R, Bouyer J . High reproducibility of serum anti-Mullerian hormone measurements suggests a multi-staged follicular secretion and strengthens its role in the assessment of ovarian follicular status. Hum Reprod. 2005; 20(4):923-7. DOI: 10.1093/humrep/deh688. View

18.

Hazout A, Bouchard P, Seifer D, Aussage P, Junca A, Cohen-Bacrie P . Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol. Fertil Steril. 2004; 82(5):1323-9. DOI: 10.1016/j.fertnstert.2004.03.061. View

19.

Durlinger A, Gruijters M, Kramer P, Karels B, Ingraham H, Nachtigal M . Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology. 2002; 143(3):1076-84. DOI: 10.1210/endo.143.3.8691. View

20.

Groome N, Illingworth P, OBrien M, Pai R, Rodger F, Mather J . Measurement of dimeric inhibin B throughout the human menstrual cycle. J Clin Endocrinol Metab. 1996; 81(4):1401-5. DOI: 10.1210/jcem.81.4.8636341. View