Selection Mapping of Loci for Quantitative Disease Resistance in a Diverse Maize Population

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 2008 Aug 30

PMID 18723892

Citations 17

Authors

Randall J Wisser

Seth C Murray

Judith M Kolkman

Hernan Ceballos

Rebecca J Nelson

Affiliations

Soon will be listed here.

Abstract

The selection response of a complex maize population improved primarily for quantitative disease resistance to northern leaf blight (NLB) and secondarily for common rust resistance and agronomic phenotypes was investigated at the molecular genetic level. A tiered marker analysis with 151 simple sequence repeat (SSR) markers in 90 individuals of the population indicated that on average six alleles per locus were available for selection. An improved test statistic for selection mapping was developed, in which quantitative trait loci (QTL) are identified through the analysis of allele-frequency shifts at mapped multiallelic loci over generations of selection. After correcting for the multiple tests performed, 25 SSR loci showed evidence of selection. Many of the putatively selected loci were unlinked and dispersed across the genome, which was consistent with the diffuse distribution of previously published QTL for NLB resistance. Compelling evidence for selection was found on maize chromosome 8, where several putatively selected loci colocalized with published NLB QTL and a race-specific resistance gene. Analysis of F2 populations derived from the selection mapping population suggested that multiple linked loci in this chromosomal segment were, in part, responsible for the selection response for quantitative resistance to NLB.

Citing Articles

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A genomic analysis of the University of Nebraska Replicated Recurrent Selection program.

Lamkey C, Lorenz A Theor Appl Genet. 2023; 136(12):243.

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The recent evolutionary rescue of a staple crop depended on over half a century of global germplasm exchange.

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