» Articles » PMID: 18721909

MIF in Autoimmunity and Novel Therapeutic Approaches

Overview
Journal Autoimmun Rev
Publisher Elsevier
Date 2008 Aug 30
PMID 18721909
Citations 29
Authors
Affiliations
Soon will be listed here.
Abstract

Macrophage migration inhibitory factor (MIF) is a multipotent cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune disorders. Since anti-cytokine therapy is considered to be a promising therapeutic strategy, selective targeting of MIF with either anti-MIF antibody or specific chemical MIF inhibitors might offer new therapeutic avenues for these disorders. Considering the unique relationship between MIF and glucocorticoids, therapeutic antagonism of MIF could also represent an effective approach for steroid-sparing therapies in patients with refractory autoimmune diseases.

Citing Articles

Increased macrophage migration inhibitory factor is associated with inflammation in patients with rheumatoid arthritis.

Wu H, Yin F, Wang Y, Tang Z, Hong H, Jiang T Clin Rheumatol. 2025; .

PMID: 39953337 DOI: 10.1007/s10067-025-07361-8.


Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma.

Strijker J, Pascual-Pasto G, Grothusen G, Kalmeijer Y, Kalaitsidou E, Zhao C Eur J Cancer. 2025; 218:115263.

PMID: 39908652 PMC: 11884407. DOI: 10.1016/j.ejca.2025.115263.


Human embryonic stem cells secrete macrophage migration inhibitory factor: A novel finding.

Wei Y, Zheng X, Huang T, Zhong Y, Sun S, Wei X PLoS One. 2023; 18(8):e0288281.

PMID: 37616250 PMC: 10449177. DOI: 10.1371/journal.pone.0288281.


A MYCN-independent mechanism mediating secretome reprogramming and metastasis in -amplified neuroblastoma.

Zhang H, Delaidelli A, Javed S, Turgu B, Morrison T, Hughes C Sci Adv. 2023; 9(34):eadg6693.

PMID: 37611092 PMC: 10446492. DOI: 10.1126/sciadv.adg6693.


Evaluation of the Involvement of Heme Oxygenase-1 Expression in Discoid Lupus Erythematosus Lesions.

Fagone P, Piombino E, Mangano K, De Pasquale R, Nicoletti F, Caltabiano R Antioxidants (Basel). 2023; 12(7).

PMID: 37507892 PMC: 10376595. DOI: 10.3390/antiox12071352.