The Effect of Bed Rest and an Exercise Countermeasure on Leg Venous Function

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2008 Aug 23

PMID 18719936

Citations 7

Authors

Noortje T L van Duijnhoven

Michiel W P Bleeker

Patricia C E De Groot

Dick H J Thijssen

Dieter Felsenberg

Jorn Rittweger

Maria T E Hopman

Affiliations

Soon will be listed here.

Abstract

This study was performed to assess the effect of resistive vibration exercise during bed rest deconditioning on venous vascular dimension and function, as measured with ultrasound in the popliteal vein. Sixteen men were assigned to bed rest (BR-Ctrl) or bed rest with resistive vibration exercise (BR-RVE). Before and at 25 and 52 days of bed rest, popliteal vein diameter was measured at increasing cuff pressures. Venous capacitance and compliance were calculated from the pressure-volume curve. After 52 days of bed rest, BR-Ctrl showed no change in baseline popliteal vein diameter or compliance, while venous capacitance decreased. Resistive vibration exercise had no effect on the response in venous diameter, capacitance or compliance to 52 days of bed rest. The decline in venous capacitance due to long-term bed rest is not effectively counteracted by resistive vibration exercise, indicating that an alternative factor during bed rest deconditioning is responsible for venous changes.

Citing Articles

Detrimental effects of physical inactivity on peripheral and brain vasculature in humans: Insights into mechanisms, long-term health consequences and protective strategies.

Daniele A, Lucas S, Rendeiro C Front Physiol. 2022; 13:998380.

PMID: 36237532 PMC: 9553009. DOI: 10.3389/fphys.2022.998380.

Modeling individual differences in cardiovascular response to gravitational stress using a sensitivity analysis.

Whittle R, Diaz-Artiles A J Appl Physiol (1985). 2021; 130(6):1983-2001.

PMID: 33914657 PMC: 8285610. DOI: 10.1152/japplphysiol.00727.2020.

Effects of long-term head-down-tilt bed rest and different training regimes on the coagulation system of healthy men.

Haider T, Gunga H, Matteucci-Gothe R, Sottara E, Griesmacher A, Belavy D Physiol Rep. 2014; 1(6):e00135.

PMID: 24400137 PMC: 3871450. DOI: 10.1002/phy2.135.

Prolonged bed rest as adjuvant therapy after complex reconstructive spine surgery.

Marco R, Stuckey R, Holloway S Clin Orthop Relat Res. 2012; 470(6):1658-67.

PMID: 22467418 PMC: 3348306. DOI: 10.1007/s11999-012-2318-3.

Peripheral arterial and venous response to tilt test after a 60-day bedrest with and without countermeasures (ES-IBREP).

Yuan M, Coupe M, Bai Y, Gauquelin-Koch G, Jiang S, Aubry P PLoS One. 2012; 7(3):e32854.

PMID: 22412933 PMC: 3296756. DOI: 10.1371/journal.pone.0032854.

References

Akima H, Ushiyama J, Kubo J, Tonosaki S, Itoh M, Kawakami Y . Resistance training during unweighting maintains muscle size and function in human calf. Med Sci Sports Exerc. 2003; 35(4):655-62. DOI: 10.1249/01.MSS.0000058367.66796.35. View

Xiao X, Grenon S, Kim C, Sheynberg N, Hurwitz S, Williams G . Bed rest effects on human calf hemodynamics and orthostatic intolerance: a model-based analysis. Aviat Space Environ Med. 2005; 76(11):1037-45. View

Brakkee A, KUIPER J . Plethysmographic measurement of venous flow resistance in man. Vasa. 1982; 11(3):166-7. View

Wecht J, De Meersman R, Weir J, Bauman W, Grimm D . Effects of autonomic disruption and inactivity on venous vascular function. Am J Physiol Heart Circ Physiol. 2000; 278(2):H515-20. DOI: 10.1152/ajpheart.2000.278.2.H515. View

Kubo K, Akima H, Ushiyama J, Tabata I, Fukuoka H, Kanehisa H . Effects of resistance training during bed rest on the viscoelastic properties of tendon structures in the lower limb. Scand J Med Sci Sports. 2004; 14(5):296-302. DOI: 10.1046/j.1600-0838.2003.00368.x. View

Monahan K, Dinenno F, Seals D, Halliwill J . Smaller age-associated reductions in leg venous compliance in endurance exercise-trained men. Am J Physiol Heart Circ Physiol. 2001; 281(3):H1267-73. DOI: 10.1152/ajpheart.2001.281.3.H1267. View

Convertino V . Exercise as a countermeasure for physiological adaptation to prolonged spaceflight. Med Sci Sports Exerc. 1996; 28(8):999-1014. DOI: 10.1097/00005768-199608000-00010. View

Arbeille P, Fomina G, Roumy J, Alferova I, Tobal N, Herault S . Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short- and long-term head-down tilt and spaceflights. Eur J Appl Physiol. 2002; 86(2):157-68. DOI: 10.1007/s004210100473. View

Bleeker M, de Groot P, Pawelczyk J, Hopman M, Levine B . Effects of 18 days of bed rest on leg and arm venous properties. J Appl Physiol (1985). 2003; 96(3):840-7. DOI: 10.1152/japplphysiol.00835.2003. View

10.

Arbeille P, Herault S, Fomina G, Roumy J, Alferova I, Gharib C . Influences of thigh cuffs on the cardiovascular system during 7-day head-down bed rest. J Appl Physiol (1985). 1999; 87(6):2168-76. DOI: 10.1152/jappl.1999.87.6.2168. View

11.

Bleeker M, De Groot P, Rongen G, Rittweger J, Felsenberg D, Smits P . Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study. J Appl Physiol (1985). 2005; 99(4):1293-300. DOI: 10.1152/japplphysiol.00118.2005. View

12.

Pointel J, Gin H, Drouin P, Vernhes G, DEBRY G . Venous plethysmography: measuring techniques and normal values. Angiology. 1981; 32(3):145-54. DOI: 10.1177/000331978103200301. View

13.

Louisy F, Schroiff P, Guell A . Changes in leg vein filling and emptying characteristics and leg volumes during long-term head-down bed rest. J Appl Physiol (1985). 1997; 82(6):1726-33. DOI: 10.1152/jappl.1997.82.6.1726. View

14.

Rittweger J, Beller G, Felsenberg D . Acute physiological effects of exhaustive whole-body vibration exercise in man. Clin Physiol. 2000; 20(2):134-42. DOI: 10.1046/j.1365-2281.2000.00238.x. View

15.

Hopman M, Nommensen E, van Asten W, Oeseburg B, Binkhorst R . Properties of the venous vascular system in the lower extremities of individuals with paraplegia. Paraplegia. 1994; 32(12):810-6. DOI: 10.1038/sc.1994.128. View

16.

Buckey J, Lane L, Plath G, Gaffney F, Baisch F, Blomqvist C . Effects of head-down tilt for 10 days on the compliance of the leg. Acta Physiol Scand Suppl. 1992; 604:53-9. View

17.

Mulder E, Stegeman D, Gerrits K, Paalman M, Rittweger J, Felsenberg D . Strength, size and activation of knee extensors followed during 8 weeks of horizontal bed rest and the influence of a countermeasure. Eur J Appl Physiol. 2006; 97(6):706-15. DOI: 10.1007/s00421-006-0241-6. View

18.

Madhavan G, Stewart J, McLeod K . Cardiovascular systemic regulation by plantar surface stimulation. Biomed Instrum Technol. 2006; 40(1):78-84. DOI: 10.2345/0899-8205(2006)40[78:CSRBPS]2.0.CO;2. View

19.

Miyachi M, Tanaka H, Yamamoto K, Yoshioka A, Takahashi K, Onodera S . Effects of one-legged endurance training on femoral arterial and venous size in healthy humans. J Appl Physiol (1985). 2001; 90(6):2439-44. DOI: 10.1152/jappl.2001.90.6.2439. View

20.

Watenpaugh D, Buckey J, Lane L, Gaffney F, Levine B, Moore W . Effects of spaceflight on human calf hemodynamics. J Appl Physiol (1985). 2001; 90(4):1552-8. DOI: 10.1152/jappl.2001.90.4.1552. View