Genetically Divergent Strains of Feline Immunodeficiency Virus from the Domestic Cat (Felis Catus) and the African Lion (Panthera Leo) Share Usage of CD134 and CXCR4 As Entry Receptors

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2008 Aug 22

PMID 18715917

Citations 3

Authors

William A McEwan

Elizabeth L McMonagle

Nicola Logan

Rodrigo C Serra

Pieter Kat

Sue VandeWoude

Margaret J Hosie

Brian J Willett

Affiliations

Soon will be listed here.

Abstract

The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIV(Ple)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(Ple)-E sharing a common ancestor with the domestic cat (Felis catus) lentivirus (FIV(Fca)). Here we demonstrate that FIV(Ple)-E and FIV(Fca) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(Ple)-E. The shared usage of CD134 and CXCR4 by FIV(Fca) and FIV(Ple)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.

Citing Articles

Feline immunodeficiency virus in South America.

Teixeira B, Hagiwara M, Cruz J, Hosie M Viruses. 2012; 4(3):383-396.

PMID: 22590677 PMC: 3347033. DOI: 10.3390/v4030383.

The molecular biology of feline immunodeficiency virus (FIV).

Kenyon J, Lever A Viruses. 2011; 3(11):2192-213.

PMID: 22163340 PMC: 3230847. DOI: 10.3390/v3112192.

Restrictions to cross-species transmission of lentiviral infection gleaned from studies of FIV.

VandeWoude S, Troyer J, Poss M Vet Immunol Immunopathol. 2009; 134(1-2):25-32.

PMID: 19896218 PMC: 2822018. DOI: 10.1016/j.vetimm.2009.10.005.

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