Waist Circumference Cut-off Points for the Diagnosis of Metabolic Syndrome in Iranian Adults

Overview

Journal Diabetes Res Clin Pract

Specialty Endocrinology

Date 2008 Aug 19

PMID 18706730

Citations 30

Authors

Alireza Esteghamati

Haleh Ashraf

Armin Rashidi

Alipasha Meysamie

Affiliations

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Abstract

Aims: Central obesity, a prominent feature of metabolic syndrome (MetS), is commonly assessed by gender- and ethnicity-specific waist circumference (WC) cut-off values. Since 2006, the recommended WC cut-offs by the International Diabetes Federation (IDF) for Europeans are used in Iran because of limited data availability. The purpose of this study was to determine optimal cut-off points for the diagnosis of MetS in Iran.

Methods: A total of 2752 adults (1046 men) were studied. Subjects with two or more of the following risk factors from the IDF criteria were considered to have multiple risk factors: hyperglycemia (FBG>/=100mg/dL or diagnosed diabetes), high blood pressure (SBP>/=130mmHg, DBP>/=85mmHg, or using antihypertensive drugs), low HDL (<50mg/dL for females and <40mg/dL for males), and high TG (>150mg/dL).

Results: The WC cut-off yielding maximum sensitivity plus specificity for predicting the presence of multiple risk factors was 91.5cm in men and 85.5cm in women. Sensitivity and specificity were 77% (86%) and 58% (50%) in men (women), respectively. MetS prevalence was estimated to be approximately 27% in Tehran.

Conclusions: WC cut-offs recommended by the IDF are not appropriate for use in Iran.

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