Applications of Next-generation Sequencing Technologies in Functional Genomics

Overview

Journal Genomics

Specialty Genetics

Date 2008 Aug 16

PMID 18703132

Citations 407

Authors

Olena Morozova

Marco A Marra

Affiliations

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Abstract

A new generation of sequencing technologies, from Illumina/Solexa, ABI/SOLiD, 454/Roche, and Helicos, has provided unprecedented opportunities for high-throughput functional genomic research. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted resequencing, discovery of transcription factor binding sites, and noncoding RNA expression profiling. This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer.

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