Knockout Mice Reveal a Role for Protein Tyrosine Phosphatase H1 in Cognition

Overview

Journal Behav Brain Funct

Publisher Biomed Central

Specialties Neurology
Psychology
Social Sciences

Date 2008 Aug 14

PMID 18700002

Citations 1

Authors

Claudia Patrignani

Maria Chiara Magnone

Patrizia Tavano

Michele Ardizzone

Valeria Muzio

Beatrice Greco

Paola F Zaratin

Affiliations

Soon will be listed here.

Abstract

Background: The present study has investigated the protein tyrosine phosphatase H1 (PTPH1) expression pattern in mouse brain and its impact on CNS functions.

Methods: We have previously described a PTPH1-KO mouse, generated by replacing the PTP catalytic and the PDZ domain with a LacZ neomycin cassette. PTPH1 expression pattern was evaluated by LacZ staining in the brain and PTPH1-KO and WT mice (n = 10 per gender per genotype) were also behaviorally tested for CNS functions.

Results: In CNS, PTPH1 is expressed during development and in adulthood and mainly localized in hippocampus, thalamus, cortex and cerebellum neurons. The behavioral tests performed on the PTPH1-KO mice showed an impact on working memory in male mice and an impaired learning performance at rotarod in females.

Conclusion: These results demonstrate for the first time a neuronal expression of PTPH1 and its functionality at the level of cognition.

Citing Articles

The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.

Bauler T, Hendriks W, King P PLoS One. 2008; 3(12):e4014.

PMID: 19107198 PMC: 2602985. DOI: 10.1371/journal.pone.0004014.

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