Stem Cells for End Stage Liver Disease: How Far Have We Got?

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2008 Aug 14

PMID 18698672

Citations 18

Authors

Stefania Lorenzini

Stefano Gitto

Elena Grandini

Pietro Andreone

Mauro Bernardi

Affiliations

Soon will be listed here.

Abstract

End stage liver disease (ESLD) is a health problem worldwide. Liver transplantation is currently the only effective therapy, but its many drawbacks include a shortage of donors, operative damage, risk of rejection and in some cases recidivism of the pre-transplant disease. These factors account for the recent growing interest in regenerative medicine. Experiments have sought to identify an optimal source of stem cells, sufficient to generate large amounts of hepatocytes to be used in bioartificial livers or injected in vivo to repair the diseased organ. This update aims to give non-stem cell specialists an overview of the results obtained to date in this fascinating field of biomedical research.

Citing Articles

Adult Stem Cell Therapy as Regenerative Medicine for End-Stage Liver Disease.

Sukowati C, Tiribelli C Adv Exp Med Biol. 2022; 1401:57-72.

PMID: 35915364 DOI: 10.1007/5584_2022_719.

Functional characterization of CD49f hepatic stem/progenitor cells in adult mice liver.

Guo Z, Pu S, Li Y, Wang X, Hu S, Zhao H J Mol Histol. 2022; 53(2):239-256.

PMID: 35166962 DOI: 10.1007/s10735-022-10063-z.

Prednisolone and mesenchymal stem cell preloading protect liver cell migration and mitigate extracellular matrix modification in transplanted decellularized rat liver.

Yaghoubi A, Azarpira N, Karbalay-Doust S, Daneshi S, Vojdani Z, Talaei-Khozani T Stem Cell Res Ther. 2022; 13(1):36.

PMID: 35090559 PMC: 8800282. DOI: 10.1186/s13287-022-02711-8.

Overexpression of c-Met in bone marrow mesenchymal stem cells improves their effectiveness in homing and repair of acute liver failure.

Wang K, Li Y, Zhu T, Zhang Y, Li W, Lin W Stem Cell Res Ther. 2017; 8(1):162.

PMID: 28679425 PMC: 5499016. DOI: 10.1186/s13287-017-0614-2.

Therapeutic Potential of Bone Marrow-Derived Mesenchymal Stem Cells on Experimental Liver Injury Induced by Schistosoma mansoni: A Histological Study.

Fikry H, Gawad S, Baher W Int J Stem Cells. 2016; 9(1):96-106.

PMID: 27426091 PMC: 4961109. DOI: 10.15283/ijsc.2016.9.1.96.

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