Chromosomal Alterations Detected by Comparative Genomic Hybridization in Subgroups of Gene Expression-defined Burkitt's Lymphoma

Overview

Journal Haematologica

Specialty Hematology

Date 2008 Aug 14

PMID 18698080

Citations 24

Authors

Itziar Salaverria

Andreas Zettl

Silvia Bea

Elena M Hartmann

Sandeep S Dave

George W Wright

Evert-Jan Boerma

Philip M Kluin

German Ott

Wing C Chan

Dennis D Weisenburger

Armando Lopez-Guillermo

Randy D Gascoyne

Jan Delabie

Lisa M Rimsza

Rita M Braziel

Elaine S Jaffe

Louis M Staudt

Hans Konrad Muller-Hermelink

Elias Campo

Andreas Rosenwald

Affiliations

Soon will be listed here.

Abstract

Background: Burkitt's lymphoma is an aggressive B-cell lymphoma characterized by typical morphological, immunophenotypic and molecular features. Gene expression profiling provided a molecular signature of Burkitt's lymphoma, but also demonstrated that a subset of aggressive B-cell lymphomas not fulfilling the current World Health Organization criteria for the diagnosis of Burkitt's lymphoma nonetheless show a molecular signature of Burkitt's lymphoma ('discrepant Burkitt's lymphoma'). Given the different treatment of Burkitt's lymphoma and diffuse large B-cell lymphomas we investigated molecular differences within gene expression-defined Burkitt's lymphoma.

Design And Methods: We studied tumors from 51 Burkitt's lymphoma patients, comprising 26 with classic Burkitt's lymphoma, 17 with atypical Burkitt's lymphoma and 8 with 'discrepant Burkitt's lymphoma', by comparative genomic hybridization and gene expression profiling.

Results: Classic and atypical Burkitt's lymphoma (excluding 'discrepant Burkitt's lymphoma'), in adult and pediatric cases do not differ in underlying genomic imbalances or gene expression suggesting that these subgroups are molecularly homogeneous. 'Discrepant Burkitt's lymphoma', however, differ dramatically in the absolute number of alterations from classic/atypical Burkitt's lymphoma and from diffuse large B-cell lymphoma. Moreover, this category includes lymphomas that carry both the t(14;18) and t(8;14) translocations and are clinically characterized by presentation in adult patients and an aggressive course.

Conclusions: Pediatric and adult Burkitt's lymphoma are molecularly homogeneous, whereas 'discrepant Burkitt's lymphoma' differ in underlying genetic and clinical features from typical/atypical Burkitt's lymphoma. 'Discrepant Burkitt's lymphoma' may therefore form a distinct genetic subgroup of aggressive B-cell lymphomas, which show poor response to multi-agent chemotherapy.

Citing Articles

EBV and 1q Gains Affect Gene and miRNA Expression in Burkitt Lymphoma.

Akyuz N, Janjetovic S, Ghandili S, Bokemeyer C, Dierlamm J Viruses. 2023; 15(9).

PMID: 37766215 PMC: 10537407. DOI: 10.3390/v15091808.

High-grade B-cell lymphoma with 11q aberrations: A single-center study.

Yamada S, Oka Y, Muramatsu M, Hashimoto Y J Clin Exp Hematop. 2023; 63(2):121-131.

PMID: 37380468 PMC: 10410621. DOI: 10.3960/jslrt.23007.

Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma.

Thomas N, Dreval K, Gerhard D, Hilton L, Abramson J, Ambinder R Blood. 2022; 141(8):904-916.

PMID: 36201743 PMC: 10023728. DOI: 10.1182/blood.2022016534.

Current understanding of the role and regulation of miRNAs in Burkitt lymphoma.

Videtta A, Malagnino V, De Falco G Blood Lymphat Cancer. 2019; 8:33-45.

PMID: 31360092 PMC: 6467348. DOI: 10.2147/BLCTT.S129618.

Adult high-grade B-cell lymphoma with Burkitt lymphoma signature: genomic features and potential therapeutic targets.

Bouska A, Bi C, Lone W, Zhang W, Kedwaii A, Heavican T Blood. 2017; 130(16):1819-1831.

PMID: 28801451 PMC: 5649549. DOI: 10.1182/blood-2017-02-767335.

References

Smeland S, Blystad A, Kvaloy S, Ikonomou I, Delabie J, Kvalheim G . Treatment of Burkitt's/Burkitt-like lymphoma in adolescents and adults: a 20-year experience from the Norwegian Radium Hospital with the use of three successive regimens. Ann Oncol. 2004; 15(7):1072-8. DOI: 10.1093/annonc/mdh262. View

Bea S, Zettl A, Wright G, Salaverria I, Jehn P, Moreno V . Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood. 2005; 106(9):3183-90. PMC: 1895326. DOI: 10.1182/blood-2005-04-1399. View

Wessendorf S, Schwaenen C, Kohlhammer H, Kienle D, Wrobel G, Barth T . Hidden gene amplifications in aggressive B-cell non-Hodgkin lymphomas detected by microarray-based comparative genomic hybridization. Oncogene. 2003; 22(9):1425-9. DOI: 10.1038/sj.onc.1206297. View

Onciu M, Schlette E, Zhou Y, Raimondi S, Giles F, Kantarjian H . Secondary chromosomal abnormalities predict outcome in pediatric and adult high-stage Burkitt lymphoma. Cancer. 2006; 107(5):1084-92. DOI: 10.1002/cncr.22089. View

Dave S, Fu K, Wright G, Lam L, Kluin P, Boerma E . Molecular diagnosis of Burkitt's lymphoma. N Engl J Med. 2006; 354(23):2431-42. DOI: 10.1056/NEJMoa055759. View

Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth T . A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med. 2006; 354(23):2419-30. DOI: 10.1056/NEJMoa055351. View

Bishop P, Rao V, Wilson W . Burkitt's lymphoma: molecular pathogenesis and treatment. Cancer Invest. 2000; 18(6):574-83. DOI: 10.3109/07357900009012197. View

Karpova M, Schoumans J, Blennow E, Ernberg I, Henter J, Smirnov A . Combined spectral karyotyping, comparative genomic hybridization, and in vitro apoptyping of a panel of Burkitt's lymphoma-derived B cell lines reveals an unexpected complexity of chromosomal aberrations and a recurrence of specific abnormalities in.... Int J Oncol. 2006; 28(3):605-17. View

Kanungo A, Medeiros L, Abruzzo L, Lin P . Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis. Mod Pathol. 2005; 19(1):25-33. DOI: 10.1038/modpathol.3800500. View

10.

Lones M, Sanger W, Le Beau M, Heerema N, Sposto R, Perkins S . Chromosome abnormalities may correlate with prognosis in Burkitt/Burkitt-like lymphomas of children and adolescents: a report from Children's Cancer Group Study CCG-E08. J Pediatr Hematol Oncol. 2004; 26(3):169-78. DOI: 10.1097/00043426-200403000-00006. View

11.

Pienkowska-Grela B, Witkowska A, Grygalewicz B, Rymkiewicz G, Rygier J, Woroniecka R . Frequent aberrations of chromosome 8 in aggressive B-cell non-Hodgkin lymphoma. Cancer Genet Cytogenet. 2005; 156(2):114-21. DOI: 10.1016/j.cancergencyto.2004.04.009. View

12.

Salaverria I, Zettl A, Bea S, Moreno V, Valls J, Hartmann E . Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signature. J Clin Oncol. 2007; 25(10):1216-22. PMC: 2366164. DOI: 10.1200/JCO.2006.08.4251. View

13.

Lossos I . Molecular pathogenesis of diffuse large B-cell lymphoma. J Clin Oncol. 2005; 23(26):6351-7. DOI: 10.1200/JCO.2005.05.012. View

14.

Barth T, Muller S, Pawlita M, Siebert R, Rother J, Mechtersheimer G . Homogeneous immunophenotype and paucity of secondary genomic aberrations are distinctive features of endemic but not of sporadic Burkitt's lymphoma and diffuse large B-cell lymphoma with MYC rearrangement. J Pathol. 2004; 203(4):940-5. DOI: 10.1002/path.1596. View

15.

Garcia J, Hernandez J, Gutierrez N, Flores T, Gonzalez D, Calasanz M . Abnormalities on 1q and 7q are associated with poor outcome in sporadic Burkitt's lymphoma. A cytogenetic and comparative genomic hybridization study. Leukemia. 2003; 17(10):2016-24. DOI: 10.1038/sj.leu.2403080. View

16.

Zettl A, Ott G, Makulik A, Katzenberger T, Starostik P, Eichler T . Chromosomal gains at 9q characterize enteropathy-type T-cell lymphoma. Am J Pathol. 2002; 161(5):1635-45. PMC: 1850794. DOI: 10.1016/S0002-9440(10)64441-0. View

17.

Divine M, Casassus P, Koscielny S, Bosq J, Sebban C, Le Maignan C . Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol. Ann Oncol. 2005; 16(12):1928-35. DOI: 10.1093/annonc/mdi403. View

18.

MacPHERSON N, Lesack D, Klasa R, Horsman D, Connors J, Barnett M . Small noncleaved, non-Burkitt's (Burkit-Like) lymphoma: cytogenetics predict outcome and reflect clinical presentation. J Clin Oncol. 1999; 17(5):1558-67. DOI: 10.1200/JCO.1999.17.5.1558. View