Morphogen Control of Wing Growth Through the Fat Signaling Pathway

Overview

Journal Dev Cell

Publisher Cell Press

Specialties Cell Biology
Reproductive Medicine

Date 2008 Aug 13

PMID 18694569

Citations 135

Authors

Dragana Rogulja

Cordelia Rauskolb

Kenneth D Irvine

Affiliations

Soon will be listed here.

Abstract

Organ growth is influenced by organ patterning, but the molecular mechanisms that link patterning to growth have remained unclear. We show that the Dpp morphogen gradient in the Drosophila wing influences growth by modulating the activity of the Fat signaling pathway. Dpp signaling regulates the expression and localization of Fat pathway components, and Fat signaling through Dachs is required for the effect of the Dpp gradient on cell proliferation. Juxtaposition of cells that express different levels of the Fat pathway regulators four-jointed and dachsous stimulates expression of Fat/Hippo pathway target genes and cell proliferation, consistent with the hypothesis that the graded expression of these genes contributes to wing growth. Moreover, uniform expression of four-jointed and dachsous in the wing inhibits cell proliferation. These observations identify Fat as a signaling pathway that links the morphogen-mediated establishment of gradients of positional values across developing organs to the regulation of organ growth.

Citing Articles

Contributions of the Dachsous intracellular domain to Dachsous-Fat signaling.

Tripathi B, Irvine K Development. 2024; 151(23).

PMID: 39503213 PMC: 11634027. DOI: 10.1242/dev.202919.

Dachsous and Fat coordinately repress the Dachs-Dlish-Approximated complex to control growth.

Matakatsu H, Fehon R J Cell Biol. 2024; 223(12).

PMID: 39373700 PMC: 11461286. DOI: 10.1083/jcb.202406119.

Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in .

Liu A, OConnell J, Wall F, Carthew R Elife. 2024; 12.

PMID: 38842917 PMC: 11156469. DOI: 10.7554/eLife.91572.

Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in .

Liu A, OConnell J, Wall F, Carthew R bioRxiv. 2024; .

PMID: 38645118 PMC: 11030236. DOI: 10.1101/2023.08.01.551465.

Hippo pathway in cell-cell communication: emerging roles in development and regeneration.

Nita A, Moroishi T Inflamm Regen. 2024; 44(1):18.

PMID: 38566194 PMC: 10986044. DOI: 10.1186/s41232-024-00331-8.

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