Dynamic Length Regulation of Sensory Stereocilia

Overview

Journal Semin Cell Dev Biol

Specialties Cell Biology
Reproductive Medicine

Date 2008 Aug 12

PMID 18692583

Citations 55

Authors

Uri Manor

Bechara Kachar

Affiliations

Soon will be listed here.

Abstract

Stereocilia, the mechanosensory organelles of hair cells, are a distinctive class of actin-based cellular protrusions with an unparalleled ability to regulate their lengths over time. Studies on actin turnover in stereocilia, as well as the identification of several deafness-related proteins essential for proper stereocilia structure and function, provide new insights into the mechanisms and molecules involved in stereocilia length regulation and long-term maintenance. Comparisons of ongoing investigations on stereocilia with studies on other actin protrusions offer new opportunities to further understand common principles for length regulation, the diversity of its mechanisms, and how the specific needs of each cell are met.

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References

Mogilner A, Rubinstein B . The physics of filopodial protrusion. Biophys J. 2005; 89(2):782-95. PMC: 1366629. DOI: 10.1529/biophysj.104.056515. View

Grati M, Schneider M, Lipkow K, Strehler E, Wenthold R, Kachar B . Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2. J Neurosci. 2006; 26(23):6386-95. PMC: 1949025. DOI: 10.1523/JNEUROSCI.1215-06.2006. View

Bashtanov M, Goodyear R, Richardson G, Russell I . The mechanical properties of chick (Gallus domesticus) sensory hair bundles: relative contributions of structures sensitive to calcium chelation and subtilisin treatment. J Physiol. 2004; 559(Pt 1):287-99. PMC: 1665060. DOI: 10.1113/jphysiol.2004.065565. View

Zigmond S . Formin-induced nucleation of actin filaments. Curr Opin Cell Biol. 2004; 16(1):99-105. DOI: 10.1016/j.ceb.2003.10.019. View

Gillespie P, Cyr J . Myosin-1c, the hair cell's adaptation motor. Annu Rev Physiol. 2004; 66:521-45. DOI: 10.1146/annurev.physiol.66.032102.112842. View

Littlewood Evans A, Muller U . Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet. 2000; 24(4):424-8. DOI: 10.1038/74286. View

Ricci A, Kachar B, Gale J, Van Netten S . Mechano-electrical transduction: new insights into old ideas. J Membr Biol. 2006; 209(2-3):71-88. PMC: 1839004. DOI: 10.1007/s00232-005-0834-8. View

Hughes S, Fehon R . Understanding ERM proteins--the awesome power of genetics finally brought to bear. Curr Opin Cell Biol. 2006; 19(1):51-6. DOI: 10.1016/j.ceb.2006.12.004. View

Gupton S, Anderson K, Kole T, Fischer R, Ponti A, Hitchcock-DeGregori S . Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol. 2005; 168(4):619-31. PMC: 2171771. DOI: 10.1083/jcb.200406063. View

10.

Sekerkova G, Zheng L, Loomis P, Mugnaini E, Bartles J . Espins and the actin cytoskeleton of hair cell stereocilia and sensory cell microvilli. Cell Mol Life Sci. 2006; 63(19-20):2329-41. PMC: 2522319. DOI: 10.1007/s00018-006-6148-x. View

11.

Longo-Guess C, Gagnon L, Cook S, Wu J, Zheng Q, Johnson K . A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Proc Natl Acad Sci U S A. 2005; 102(22):7894-9. PMC: 1142366. DOI: 10.1073/pnas.0500760102. View

12.

Mitchem K, Hibbard E, Beyer L, Bosom K, Dootz G, Dolan D . Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. Hum Mol Genet. 2002; 11(16):1887-98. DOI: 10.1093/hmg/11.16.1887. View

13.

Dose A, Burnside B . Cloning and chromosomal localization of a human class III myosin. Genomics. 2000; 67(3):333-42. DOI: 10.1006/geno.2000.6256. View

14.

Kambara T, Komaba S, Ikebe M . Human myosin III is a motor having an extremely high affinity for actin. J Biol Chem. 2006; 281(49):37291-301. DOI: 10.1074/jbc.M603823200. View

15.

Mustapha M, Beyer L, Izumikawa M, Swiderski D, Dolan D, Raphael Y . Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants. J Assoc Res Otolaryngol. 2007; 8(3):329-37. PMC: 2538434. DOI: 10.1007/s10162-007-0083-x. View

16.

Walsh T, Walsh V, Vreugde S, Hertzano R, Shahin H, Haika S . From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proc Natl Acad Sci U S A. 2002; 99(11):7518-23. PMC: 124268. DOI: 10.1073/pnas.102091699. View

17.

Donaudy F, Ferrara A, Esposito L, Hertzano R, Ben-David O, Bell R . Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss. Am J Hum Genet. 2003; 72(6):1571-7. PMC: 1180318. DOI: 10.1086/375654. View

18.

Brown S, Hardisty-Hughes R, Mburu P . Quiet as a mouse: dissecting the molecular and genetic basis of hearing. Nat Rev Genet. 2008; 9(4):277-90. DOI: 10.1038/nrg2309. View

19.

Mogilner A, Oster G . Force generation by actin polymerization II: the elastic ratchet and tethered filaments. Biophys J. 2003; 84(3):1591-605. PMC: 1302730. DOI: 10.1016/S0006-3495(03)74969-8. View

20.

Prost J, Barbetta C, Joanny J . Dynamical control of the shape and size of stereocilia and microvilli. Biophys J. 2007; 93(4):1124-33. PMC: 1929046. DOI: 10.1529/biophysj.106.098038. View