Chemoenzymatic Acylation of Aminoglycoside Antibiotics

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2008 Aug 8

PMID 18685777

Citations 12

Authors

Nicholas M Llewellyn

Jonathan B Spencer

Affiliations

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Abstract

The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.

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