Genetics of Irritable Bowel Syndrome

Overview

Journal Am J Gastroenterol

Specialty Gastroenterology

Date 2008 Aug 8

PMID 18684190

Citations 22

Authors

Yuri A Saito

Nicholas J Talley

Affiliations

Soon will be listed here.

Abstract

Irritable bowel syndrome (IBS) is one of the most common diagnoses made by gastroenterologists and primary care providers alike, and yet the underlying mechanism remains poorly understood. Family and twin studies suggest that IBS may have a genetic basis. Several candidate gene association studies have been performed, but thus far, they have failed to clearly identify an "IBS gene." Epidemiological studies are needed to facilitate phenotype definition and identify relevant environment risk factors that will need to factor in gene and environment interactions in all future genetic studies. As genetic research in IBS is relatively nascent, much opportunity, as well as many challenges, exists in identifying the genes responsible for IBS.

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References

Gonsalkorale W, Perrey C, Pravica V, Whorwell P, Hutchinson I . Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?. Gut. 2002; 52(1):91-3. PMC: 1773523. DOI: 10.1136/gut.52.1.91. View

Talley N, Boyce P, Nandurkar S, Andrews G . Evidence of a genetic contribution to functional bowel disorder. Am J Gastroenterol. 1998; 93(8):1311-7. DOI: 10.1111/j.1572-0241.1998.440_j.x. View

Kim H, Camilleri M, Carlson P, Cremonini F, Ferber I, Stephens D . Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut. 2004; 53(6):829-37. PMC: 1774073. DOI: 10.1136/gut.2003.030882. View

van der Veek P, van den Berg M, de Kroon Y, Verspaget H, Masclee A . Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome. Am J Gastroenterol. 2005; 100(11):2510-6. DOI: 10.1111/j.1572-0241.2005.00257.x. View

Levy R, Whitehead W, Von Korff M, Feld A . Intergenerational transmission of gastrointestinal illness behavior. Am J Gastroenterol. 2000; 95(2):451-6. DOI: 10.1111/j.1572-0241.2000.01766.x. View

Pata C, Erdal E, Yazc K, Camdeviren H, Ozkaya M, Ulu O . Association of the -1438 G/A and 102 T/C polymorphism of the 5-Ht2A receptor gene with irritable bowel syndrome 5-Ht2A gene polymorphism in irritable bowel syndrome. J Clin Gastroenterol. 2004; 38(7):561-6. DOI: 10.1097/00004836-200408000-00005. View

Camilleri M, Atanasova E, Carlson P, Ahmad U, Jae Kim H, Viramontes B . Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome. Gastroenterology. 2002; 123(2):425-32. DOI: 10.1053/gast.2002.34780. View

Lee D, Park H, Kim W, Lee S, Seo Y, Choi Y . [Serotonin transporter gene polymorphism in healthy adults and patients with irritable bowel syndrome]. Korean J Gastroenterol. 2004; 43(1):18-22. View

Whorwell P, McCallum M, Creed F, Roberts C . Non-colonic features of irritable bowel syndrome. Gut. 1986; 27(1):37-40. PMC: 1433171. DOI: 10.1136/gut.27.1.37. View

10.

Yeo A, Boyd P, Lumsden S, Saunders T, Handley A, Stubbins M . Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women. Gut. 2004; 53(10):1452-8. PMC: 1774243. DOI: 10.1136/gut.2003.035451. View

11.

Saito Y, Locke 3rd G, Zimmerman J, Holtmann G, Slusser J, de Andrade M . A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome. Neurogastroenterol Motil. 2007; 19(6):465-70. DOI: 10.1111/j.1365-2982.2007.00905.x. View

12.

Mohammed I, Cherkas L, Riley S, Spector T, Trudgill N . Genetic influences in irritable bowel syndrome: a twin study. Am J Gastroenterol. 2005; 100(6):1340-4. DOI: 10.1111/j.1572-0241.2005.41700.x. View

13.

Ogura Y, Bonen D, Inohara N, Nicolae D, Chen F, Ramos R . A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001; 411(6837):603-6. DOI: 10.1038/35079114. View

14.

Hirschhorn J, Lohmueller K, Byrne E, Hirschhorn K . A comprehensive review of genetic association studies. Genet Med. 2002; 4(2):45-61. DOI: 10.1097/00125817-200203000-00002. View

15.

Hugot J, Chamaillard M, Zouali H, Lesage S, Cezard J, Belaiche J . Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001; 411(6837):599-603. DOI: 10.1038/35079107. View

16.

Li Y, Nie Y, Xie J, Tang W, Liang P, Sha W . The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients. Dig Dis Sci. 2007; 52(11):2942-9. DOI: 10.1007/s10620-006-9679-y. View

17.

Bengtson M, Ronning T, Vatn M, Harris J . Irritable bowel syndrome in twins: genes and environment. Gut. 2006; 55(12):1754-9. PMC: 1856463. DOI: 10.1136/gut.2006.097287. View

18.

Levy R, Jones K, Whitehead W, Feld S, Talley N, Corey L . Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterology. 2001; 121(4):799-804. DOI: 10.1053/gast.2001.27995. View

19.

Saito Y, Zimmerman J, Harmsen W, de Andrade M, Locke 3rd G, Petersen G . Irritable bowel syndrome aggregates strongly in families: a family-based case-control study. Neurogastroenterol Motil. 2008; 20(7):790-7. PMC: 2873036. DOI: 10.1111/j.1365-2982.2007.1077.x. View

20.

Kanazawa M, Endo Y, Whitehead W, Kano M, Hongo M, Fukudo S . Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress. Dig Dis Sci. 2004; 49(6):1046-53. DOI: 10.1023/b:ddas.0000034570.52305.10. View