Histoplasma Capsulatum at the Host-pathogen Interface

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2008 Aug 2

PMID 18672088

Citations 12

Authors

Joshua D Nosanchuk

Attila Gacser

Affiliations

Soon will be listed here.

Abstract

Histoplasma capsulatum is the most common cause of invasive fungal pulmonary disease worldwide. The interaction of H. capsulatum with a host is a complex, dynamic process. Severe disease most commonly occurs in individuals with compromised immunity, and the increasing utilization of immunomodulators in medicine has revealed significant risks for reactivation disease in patients with latent histoplasmosis. Fortunately, there are well developed molecular tools and excellent animal models for studying H. capsulatum virulence and numerous recent advances have been made regarding the pathogenesis of this fungus that will improve our capacity to combat disease.

Citing Articles

Pulmonary Histoplasmosis: A Clinical Update.

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C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut.

Li T, Liu L, Hou Y, Shen S, Wang T Gastroenterol Rep (Oxf). 2019; 7(5):312-321.

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Histoplasma Capsulatum: Mechanisms for Pathogenesis.

Mittal J, Ponce M, Gendlina I, Nosanchuk J Curr Top Microbiol Immunol. 2018; 422:157-191.

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Concentration-dependent protein loading of extracellular vesicles released by Histoplasma capsulatum after antibody treatment and its modulatory action upon macrophages.

Baltazar L, Zamith-Miranda D, Burnet M, Choi H, Nimrichter L, Nakayasu E Sci Rep. 2018; 8(1):8065.

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Miranda C, Jaker M, Fitzhugh-Kull V, Dever L IDCases. 2017; 11:33-35.

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