Hormesis and Medicine

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 2008 Jul 30

PMID 18662293

Citations 100

Authors

Edward J Calabrese

Affiliations

Soon will be listed here.

Abstract

Evidence is presented which supports the conclusion that the hormetic dose-response model is the most common and fundamental in the biological and biomedical sciences, being highly generalizable across biological model, endpoint measured and chemical class and physical agent. The paper provides a broad spectrum of applications of the hormesis concept for clinical medicine including anxiety, seizure, memory, stroke, cancer chemotherapy, dermatological processes such as hair growth, osteoporosis, ocular diseases, including retinal detachment, statin effects on cardiovascular function and tumour development, benign prostate enlargement, male sexual behaviours/dysfunctions, and prion diseases.

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References

Rossini M, Gatti D, Zamberlan N, Braga V, Dorizzi R, Adami S . Long-term effects of a treatment course with oral alendronate of postmenopausal osteoporosis. J Bone Miner Res. 1994; 9(11):1833-7. DOI: 10.1002/jbmr.5650091121. View

Leff P . Theoretical treatment of one-agonist-two-receptor systems. Trends Pharmacol Sci. 1994; 15(9):320; author reply 321-2. DOI: 10.1016/0165-6147(94)90022-1. View

Calabrese E, Baldwin L . Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis. Hum Exp Toxicol. 2000; 19(1):85-97. DOI: 10.1191/096032700678815620. View

Carano A, Teitelbaum S, Konsek J, Schlesinger P, Blair H . Bisphosphonates directly inhibit the bone resorption activity of isolated avian osteoclasts in vitro. J Clin Invest. 1990; 85(2):456-61. PMC: 296445. DOI: 10.1172/JCI114459. View

Thylin M, McConnell J, Schmid M, Reckling R, Ojha J, Bhattacharyya I . Effects of simvastatin gels on murine calvarial bone. J Periodontol. 2002; 73(10):1141-8. DOI: 10.1902/jop.2002.73.10.1141. View

Calabrese E, Baldwin L . Hormesis and high-risk groups. Regul Toxicol Pharmacol. 2002; 35(3):414-28. DOI: 10.1006/rtph.2001.1529. View

Biesalski H . UV light, beta-carotene and human skin--beneficial and potentially harmful effects. Arch Biochem Biophys. 2001; 389(1):1-6. DOI: 10.1006/abbi.2001.2313. View

Long M, Robinson J, Ashcraft E, Mann K . Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors. J Clin Invest. 1995; 95(2):881-7. PMC: 295576. DOI: 10.1172/JCI117738. View

Davis K, Hollister L, Overall J, Johnson A, Train K . Physostigmine: effects on cognition and affect in normal subjects. Psychopharmacology (Berl). 1976; 51(1):23-7. DOI: 10.1007/BF00426316. View

10.

Sato M, Grasser W, Endo N, Akins R, Simmons H, Thompson D . Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest. 1991; 88(6):2095-105. PMC: 295810. DOI: 10.1172/JCI115539. View

11.

Balzan S, DUrso G, Nicolini G, Forini F, Pellegrino M, Montali U . Erythrocyte sodium pump stimulation by ouabain and an endogenous ouabain-like factor. Cell Biochem Funct. 2006; 25(3):297-303. DOI: 10.1002/cbf.1387. View

12.

Korth C, May B, Cohen F, Prusiner S . Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc Natl Acad Sci U S A. 2001; 98(17):9836-41. PMC: 55539. DOI: 10.1073/pnas.161274798. View

13.

Dornand J, Kaplan J . Persistent effects of ouabain treatment on human lymphocytes: synthesis of DNA, RNA and protein in stimulated and unstimulated cells. Can J Biochem. 1976; 54(3):280-6. DOI: 10.1139/o76-041. View

14.

Foekens J, Sieuwerts A, Dorssers L, Berns E, Klijn J . Pleiotropic actions of suramin on the proliferation of human breast-cancer cells in vitro. Int J Cancer. 1992; 51(3):439-44. DOI: 10.1002/ijc.2910510317. View

15.

Laurent B, Chazot G, Michel D, Schott B . [Effects of physostigmine on amnesic syndromes (author's transl)]. Rev Neurol (Paris). 1981; 137(11):649-60. View

16.

Eichler O, Sies H, Stahl W . Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst. Photochem Photobiol. 2002; 75(5):503-6. DOI: 10.1562/0031-8655(2002)075<0503:dololc>2.0.co;2. View

17.

Muramoto O, Sugishita M, Sugita H, TOYOKURA Y . Effect of physostigmine on constructional and memory tasks in Alzheimer's disease. Arch Neurol. 1979; 36(8):501-3. DOI: 10.1001/archneur.1979.00500440071014. View

18.

Cooke J . NO and angiogenesis. Atheroscler Suppl. 2003; 4(4):53-60. DOI: 10.1016/s1567-5688(03)00034-5. View

19.

Pri-Chen S, Pitaru S, Lokiec F, Savion N . Basic fibroblast growth factor enhances the growth and expression of the osteogenic phenotype of dexamethasone-treated human bone marrow-derived bone-like cells in culture. Bone. 1998; 23(2):111-7. DOI: 10.1016/s8756-3282(98)00087-8. View

20.

Calabrese E . Historical blunders: how toxicology got the dose-response relationship half right. Cell Mol Biol (Noisy-le-grand). 2005; 51(7):643-54. View