Evolution of ADAMTS13 Antibodies in a Fatal Case of Thrombotic Thrombocytopenic Purpura

Overview

Journal Am J Hematol

Specialty Hematology

Date 2008 Jul 29

PMID 18661493

Citations 4

Authors

Lingli Dong

Visalam Chandrasekaran

Wenhua Zhou

Han-Mou Tsai

Affiliations

Soon will be listed here.

Abstract

In a patient with fatal thrombotic thrombocytopenic purpura, the inhibitory activity of antibodies against ADAMTS13 rapidly escalated to extremely high levels despite daily plasma exchange and corticosteroid therapy. This increase was found to be because of a combination of higher antibody concentration and potency. Furthermore, during her course of the disease, the percentage of IgG(1) antibody progressively decreased whereas that of IgG(2) antibody increased, suggesting Th1-type cytokine response. These changes suggest that the course of TTP may be exacerbated by complex immune reactions. Further characterization of the factors contributing to this exacerbation may have important pathogenetic and therapeutic implications.

Citing Articles

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