Histological Variants of Cutaneous Kaposi Sarcoma

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2008 Jul 29

PMID 18655700

Citations 56

Authors

Wayne Grayson

Liron Pantanowitz

Affiliations

Soon will be listed here.

Abstract

This review provides a comprehensive overview of the broad clinicopathologic spectrum of cutaneous Kaposi sarcoma (KS) lesions. Variants discussed include: usual KS lesions associated with disease progression (i.e. patch, plaque and nodular stage); morphologic subtypes alluded to in the older literature such as anaplastic and telangiectatic KS, as well as several lymphedematous variants; and numerous recently described variants including hyperkeratotic, keloidal, micronodular, pyogenic granuloma-like, ecchymotic, and intravascular KS. Involuting lesions as a result of treatment related regression are also presented.

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References

Ngendahayo P, Mets T, Bugingo G, Parkin D . [Kaposi's sarcoma in Rwanda: clinico-pathological and epidemiological aspects]. Bull Cancer. 1989; 76(4):383-94. View

Leibowitz M, Dagliotti M, Smith E, Murray J . Rapidly fatal lymphangioma-like Kaposi's sarcoma. Histopathology. 1980; 4(5):559-66. DOI: 10.1111/j.1365-2559.1980.tb02949.x. View

Ronchese F, KERN A . Lymphangioma-like tumors in Kaposi's sarcoma. AMA Arch Derm. 1957; 75(3):418-27. DOI: 10.1001/archderm.1957.01550150106015. View

Oconnell K . Kaposi's sarcoma: histopathological study of 159 cases from Malawi. J Clin Pathol. 1977; 30(8):687-95. PMC: 476526. DOI: 10.1136/jcp.30.8.687. View

Cerimele D, Carlesimo F, Fadda G, Rotoli M, Cavalieri S . Anaplastic progression of classic Kaposi's sarcoma. Dermatology. 1997; 194(3):287-9. DOI: 10.1159/000246126. View

Grayson W . The HIV-positive skin biopsy. J Clin Pathol. 2007; 61(7):802-17. DOI: 10.1136/jcp.2007.054015. View

Kalambokis G, Kitsanou M, Stergiopoulou C, Zioga A, Dimou S, Tsianos E . Lymphangioma-like Kaposi's sarcoma with gastric involvement in a patient with lung cancer. J Eur Acad Dermatol Venereol. 2005; 19(5):653-4. DOI: 10.1111/j.1468-3083.2005.01232.x. View

Mohanna S, Sanchez J, Ferrufino J, Bravo F, Gotuzzo E . Lymphangioma-like Kaposi's sarcoma: report of four cases and review. J Eur Acad Dermatol Venereol. 2006; 20(8):1010-1. DOI: 10.1111/j.1468-3083.2006.01601.x. View

Parra R, Leal M, Delgado J, Macias J, Rubio A, Gomez F . Regression of invasive AIDS-related Kaposi's sarcoma following antiretroviral therapy. Clin Infect Dis. 1998; 26(1):218-9. DOI: 10.1086/517029. View

10.

Cheung L, Rockson S . The lymphatic biology of Kaposi's sarcoma. Lymphat Res Biol. 2005; 3(1):25-35. DOI: 10.1089/lrb.2005.3.25. View

11.

Bossuyt L, van den Oord J, Degreef H . Lymphangioma-like variant of AIDS-associated Kaposi's sarcoma with pronounced edema formation. Dermatology. 1995; 190(4):324-6. DOI: 10.1159/000246731. View

12.

Miller R, Leibowitz M . The radiological features of lymphangioma-like Kaposi's sarcoma. A case report. S Afr Med J. 1979; 56(4):146-8. View

13.

Hengge U, Stocks K, Goos M . Acquired immune deficiency syndrome-related hyperkeratotic Kaposi's sarcoma with severe lymphoedema: report of five cases. Br J Dermatol. 2000; 142(3):501-5. DOI: 10.1046/j.1365-2133.2000.03364.x. View

14.

Cossu S, Satta R, Cottoni F, Massarelli G . Lymphangioma-like variant of Kaposi's sarcoma: clinicopathologic study of seven cases with review of the literature. Am J Dermatopathol. 1997; 19(1):16-22. DOI: 10.1097/00000372-199702000-00004. View

15.

Snyder R, Schwartz R . Telangiectatic Kaposi's sarcoma. Occurrence in a patient with thymoma and myasthenia gravis receiving long-term immunosuppressive therapy. Arch Dermatol. 1982; 118(12):1020-1. DOI: 10.1001/archderm.118.12.1020. View

16.

Schwartz R, Spicer M, Thomas I, Janniger C, Lambert W . Ecchymotic Kaposi's sarcoma. Cutis. 1995; 56(2):104-6. View

17.

Luzar B, Antony F, Ramdial P, Calonje E . Intravascular Kaposi's sarcoma - a hitherto unrecognized phenomenon. J Cutan Pathol. 2007; 34(11):861-4. DOI: 10.1111/j.1600-0560.2007.00734.x. View

18.

Ruocco V, Schwartz R, Ruocco E . Lymphedema: an immunologically vulnerable site for development of neoplasms. J Am Acad Dermatol. 2002; 47(1):124-7. DOI: 10.1067/mjd.2002.120909. View

19.

Wit F, Sol C, Renwick N, Roos M, Pals S, van Leeuwen R . Regression of AIDS-related Kaposi's sarcoma associated with clearance of human herpesvirus-8 from peripheral blood mononuclear cells following initiation of antiretroviral therapy. AIDS. 1998; 12(2):218-9. View

20.

Pantanowitz L, Duke W . Intravascular lesions of the hand. Diagn Pathol. 2008; 3:24. PMC: 2426672. DOI: 10.1186/1746-1596-3-24. View