The Effects of Thalidomide and Minocycline on Taxol-induced Hyperalgesia in Rats

Overview

Journal Brain Res

Specialty Neurology

Date 2008 Jul 26

PMID 18652810

Citations 50

Authors

Juan P Cata

Han-Rong Weng

Patrick M Dougherty

Affiliations

Soon will be listed here.

Abstract

Chemotherapy-induced pain is the most common treatment-limiting complication encountered by cancer patients receiving taxane-, vinca alkaloid- or platin-based chemotherapy. Several lines of evidence indicate that activation of pro-inflammatory cascades involving the release of cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and interleukin-6 (IL-6) as well as various growth factors are key events in the pathogenesis of many types of nerve-injury related pain. Similar mechanisms might also be involved in the etiology of chemotherapy-induced pain. Thalidomide and minocycline have profound immunomodulatory actions in addition to their originally intended pharmacological actions. These compounds were evaluated here for effects in preventing the development of taxol-induced mechanical and thermal hyperalgesia in rats. Thalidomide (50.0 mg/kg) reduced taxol-induced mechanical allodynia and hyperalgesia whereas minocycline (20.0 mg/kg) reduced taxol-induced mechanical hyperalgesia and allodynia as well as taxol-induced thermal hyperalgesia. These results suggest that immunomodulatory agents may provide a treatment option for the protection or reversal of chemotherapy-related pain.

Citing Articles

Evaluation of the Effect of Loratadine versus Diosmin/Hesperidin Combination on Vinca Alkaloids-Induced Neuropathy: A Randomized Controlled Clinical Trial.

Kamal N, Abdallah M, Abdel Wahed E, Sabri N, Fahmy S Pharmaceuticals (Basel). 2024; 17(5).

PMID: 38794179 PMC: 11124025. DOI: 10.3390/ph17050609.

Antimicrobial therapies for chronic pain (part 1): analgesic mechanisms.

Wang E, Karri J, Tontisirin N, Cohen S Korean J Pain. 2023; 36(3):281-298.

PMID: 37394272 PMC: 10322662. DOI: 10.3344/kjp.23129.

Protease-Activated Receptor 2 (PAR2) Expressed in Sensory Neurons Contributes to Signs of Pain and Neuropathy in Paclitaxel Treated Mice.

Kume M, Ahmad A, DeFea K, Vagner J, Dussor G, Boitano S J Pain. 2023; 24(11):1980-1993.

PMID: 37315729 PMC: 10615692. DOI: 10.1016/j.jpain.2023.06.006.

Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord.

Maixner D, Christy D, Kong L, Viatchenko-Karpinski V, Horner K, Hooks S Mol Pain. 2022; 18:17448069221107781.

PMID: 35647699 PMC: 9248043. DOI: 10.1177/17448069221107781.

Electroacupuncture Treatment Attenuates Paclitaxel-Induced Neuropathic Pain in Rats via Inhibiting Spinal Glia and the TLR4/NF-κB Pathway.

Zhao Y, Yao M, Liu Q, Xin J, Gao J, Yu X J Pain Res. 2020; 13:239-250.

PMID: 32099448 PMC: 7005725. DOI: 10.2147/JPR.S241101.

References

Dougherty P, Cata J, Cordella J, Burton A, Weng H . Taxol-induced sensory disturbance is characterized by preferential impairment of myelinated fiber function in cancer patients. Pain. 2004; 109(1-2):132-42. DOI: 10.1016/j.pain.2004.01.021. View

Bao L, Zhu Y, Elhassan A, Wu Q, Xiao B, Zhu J . Adjuvant-induced arthritis: IL-1 beta, IL-6 and TNF-alpha are up-regulated in the spinal cord. Neuroreport. 2001; 12(18):3905-8. DOI: 10.1097/00001756-200112210-00010. View

Schafers M, Brinkhoff J, Neukirchen S, Marziniak M, Sommer C . Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice. Neurosci Lett. 2001; 310(2-3):113-6. DOI: 10.1016/s0304-3940(01)02077-8. View

Forsyth P, Balmaceda C, Peterson K, Seidman A, Brasher P, DeAngelis L . Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing. J Neurooncol. 1997; 35(1):47-53. DOI: 10.1023/a:1005805907311. View

Sommer C, Schafers M, Marziniak M, Toyka K . Etanercept reduces hyperalgesia in experimental painful neuropathy. J Peripher Nerv Syst. 2001; 6(2):67-72. DOI: 10.1046/j.1529-8027.2001.01010.x. View

Zaks T, Vogel S . Induction of proinflammatory and chemokine genes by lipopolysaccharide and paclitaxel (Taxol) in murine and human breast cancer cell lines. Cytokine. 2001; 15(3):156-65. DOI: 10.1006/cyto.2001.0935. View

Geitz H, Handt S, Zwingenberger K . Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade. Immunopharmacology. 1996; 31(2-3):213-21. DOI: 10.1016/0162-3109(95)00050-x. View

Stoll G, Jung S, Jander S, van der Meide P, Hartung H . Tumor necrosis factor-alpha in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system. J Neuroimmunol. 1993; 45(1-2):175-82. DOI: 10.1016/0165-5728(93)90178-2. View

Bennett G . Does a neuroimmune interaction contribute to the genesis of painful peripheral neuropathies?. Proc Natl Acad Sci U S A. 1999; 96(14):7737-8. PMC: 33611. DOI: 10.1073/pnas.96.14.7737. View

10.

Skundric D, Dai R, James J, Lisak R . Activation of IL-1 signaling pathway in Schwann cells during diabetic neuropathy. Ann N Y Acad Sci. 2002; 958:393-8. DOI: 10.1111/j.1749-6632.2002.tb03011.x. View

11.

Tuxen M, Hansen S . Neurotoxicity secondary to antineoplastic drugs. Cancer Treat Rev. 1994; 20(2):191-214. DOI: 10.1016/0305-7372(94)90027-2. View

12.

Arruda J, Sweitzer S, Rutkowski M, DeLeo J . Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain. Brain Res. 2000; 879(1-2):216-25. DOI: 10.1016/s0006-8993(00)02807-9. View

13.

Moreira A, Sampaio E, Zmuidzinas A, Frindt P, Smith K, Kaplan G . Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med. 1993; 177(6):1675-80. PMC: 2191046. DOI: 10.1084/jem.177.6.1675. View

14.

Moos P, Fitzpatrick F . Taxane-mediated gene induction is independent of microtubule stabilization: induction of transcription regulators and enzymes that modulate inflammation and apoptosis. Proc Natl Acad Sci U S A. 1998; 95(7):3896-901. PMC: 19934. DOI: 10.1073/pnas.95.7.3896. View

15.

Kawasaki K, Gomi K, Nishijima M . Cutting edge: Gln22 of mouse MD-2 is essential for species-specific lipopolysaccharide mimetic action of taxol. J Immunol. 2000; 166(1):11-4. DOI: 10.4049/jimmunol.166.1.11. View

16.

Ledeboer A, Jekich B, Sloane E, Mahoney J, Langer S, Milligan E . Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats. Brain Behav Immun. 2006; 21(5):686-98. PMC: 2063454. DOI: 10.1016/j.bbi.2006.10.012. View

17.

Yrjanheikki J, Tikka T, Keinanen R, Goldsteins G, Chan P, Koistinaho J . A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci U S A. 1999; 96(23):13496-500. PMC: 23976. DOI: 10.1073/pnas.96.23.13496. View

18.

Sachs D, Cunha F, Poole S, Ferreira S . Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity. Pain. 2002; 96(1-2):89-97. DOI: 10.1016/s0304-3959(01)00433-x. View

19.

Shelanski M, Wisniewski H . Neurofibrillary degeneration induced by vincristine therapy. Arch Neurol. 1969; 20(2):199-206. DOI: 10.1001/archneur.1969.00480080099012. View

20.

Ding A, Porteu F, Sanchez E, Nathan C . Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science. 1990; 248(4953):370-2. DOI: 10.1126/science.1970196. View