Ceramide Inhibits CCN2 Expression in Fibroblasts

Overview

Journal J Cell Commun Signal

Date 2008 Jul 24

PMID 18649016

Citations 1

Authors

Laura Kennedy

Sunil Parapuram

Jill Greenspoon

Andrew Leask

Affiliations

Soon will be listed here.

Abstract

Connective tissue growth factor (CTGF, CCN2) is induced in response to TGFbeta in fibroblasts. In this report, we show that C2 ceramide reduced the ability of TGFbeta to induce CCN2 protein, mRNA and promoter activity in fibroblasts. C2 ceramide reduced the ability of TGFbeta to induce the generic Smad responsive promoter/reporter construct SBE-luciferase. These results suggest that C2 ceramide reduces the action of TGFbeta in fibroblasts via Smad antagonism.

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