Ghrelin Receptor Gene Polymorphisms and Body Size in Children and Adults

Overview

Journal J Clin Endocrinol Metab

Publisher Oxford University Press

Specialty Endocrinology

Date 2008 Jul 24

PMID 18647811

Citations 2

Authors

Edwin A Garcia

Barbara Heude

Clive J Petry

Maria Gueorguiev

Zaki K Hassan-Smith

Antigoni Spanou

Susan M Ring

David B Dunger

Nicholas Wareham

Manjinder S Sandhu

Ken K Ong

Marta Korbonits

Affiliations

Soon will be listed here.

Abstract

Background: The GH secretagogue receptor type 1a gene (GHSR) encodes the cognate receptor of ghrelin, a gut hormone that regulates food intake and pituitary GH secretion. Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth.

Aim: The aim of the study was to test common genetic variation in GHSR for association with body size in children and adults.

Methods: Sequencing was performed to systematically identify novel single nucleotide polymorphisms (SNPs) in GHSR. A set of three haplotype-tagging SNPs that captured all the genetic variation in GHSR was identified. These three haplotype-tagging SNPs were then genotyped in three large population-based U.K. cohort studies (two adult and one childhood cohort) comprising 5807 adults and 843 children.

Results: No significant genotype or haplotype associations were found with adult or childhood height, weight, or body mass index.

Conclusion: Common variation in GHSR is not associated with body size in U.K. adults or children.

Citing Articles

Reply to "Letter to Editor: Chronic alcohol exposure alters circulating insulin and ghrelin levels in hepatic steatosis: a translational research perspective".

Rasineni K, Casey C, Kharbanda K Am J Physiol Gastrointest Liver Physiol. 2019; 317(3):G361-G362.

PMID: 31461305 PMC: 6774088. DOI: 10.1152/ajpgi.00143.2019.

Integrating GHS into the Ghrelin System.

Veldhuis J, Bowers C Int J Pept. 2010; 2010.

PMID: 20798846 PMC: 2925380. DOI: 10.1155/2010/879503.

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