NK Gene Complex Dynamics and Selection for NK Cell Receptors

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2008 Jul 22

PMID 18640056

Citations 21

Authors

Michael G Brown

Anthony A Scalzo

Affiliations

Soon will be listed here.

Abstract

Natural killer (NK) cells play important roles in innate defense against infectious agents particularly viruses and also tumors. They mediate their effects through direct cytolysis, release of cytokines and regulation of subsequent adaptive immune responses. NK cells are equipped with sophisticated arrays of inhibitory and activation receptors that regulate their function. In this review we illustrate some of the major evolutionary relationships between NK cell receptors among different animal species and what some of the major mechanisms are that give rise to this diversity in receptor families, including the potential roles of pathogens such as viruses in driving receptor evolution.

Citing Articles

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