Functional Activation and Neural Networks in Women with Posttraumatic Stress Disorder Related to Intimate Partner Violence

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 2008 Jul 22

PMID 18639236

Citations 77

Authors

Alan N Simmons

Martin P Paulus

Steven R Thorp

Scott C Matthews

Sonya B Norman

Murray B Stein

Affiliations

Soon will be listed here.

Abstract

Background: Intimate partner violence (IPV) is one of the most common causes of posttraumatic stress disorder (PTSD) in women. Victims of IPV are often preoccupied by the anticipation of impending harm. This investigation tested the hypothesis that IPV-related PTSD individuals show exaggerated insula reactivity to the anticipation of aversive stimuli.

Methods: Fifteen women with a history of IPV and consequent PTSD (IPV-PTSD) and 15 non-traumatized control (NTC) women performed a task involving cued anticipation to images of positive and negative events during functional magnetic resonance imaging.

Results: Both groups showed increased activation of bilateral anterior insula during anticipation of negative images minus anticipation of positive images. Activation in right anterior/middle insula was significantly greater in the IPV-PTSD relative to the NTC group. Functional connectivity analysis revealed that changes in activation in right middle insula and bilateral anterior insula were more strongly associated with amygdala activation changes in NTC than in IPV-PTSD subjects.

Conclusions: This study revealed increased activation in the anterior/middle insula during negative anticipation in women with IPV-related PTSD. These findings in women with IPV could be a consequence of the IPV exposure, reflect pre-existing differences in insular function, or be due to the development of PTSD. Thus, future longitudinal studies need to examine these possibilities.

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References

Adolphs R, Damasio H, Tranel D, Cooper G, Damasio A . A role for somatosensory cortices in the visual recognition of emotion as revealed by three-dimensional lesion mapping. J Neurosci. 2000; 20(7):2683-90. PMC: 6772225. View

Bohn M, Babor T, Kranzler H . The Alcohol Use Disorders Identification Test (AUDIT): validation of a screening instrument for use in medical settings. J Stud Alcohol. 1995; 56(4):423-32. DOI: 10.15288/jsa.1995.56.423. View

Jatzko A, Schmitt A, Demirakca T, Weimer E, Braus D . Disturbance in the neural circuitry underlying positive emotional processing in post-traumatic stress disorder (PTSD). An fMRI study. Eur Arch Psychiatry Clin Neurosci. 2005; 256(2):112-4. DOI: 10.1007/s00406-005-0617-3. View

Bryant R, Felmingham K, Kemp A, Barton M, Peduto A, Rennie C . Neural networks of information processing in posttraumatic stress disorder: a functional magnetic resonance imaging study. Biol Psychiatry. 2005; 58(2):111-8. DOI: 10.1016/j.biopsych.2005.03.021. View

Stein M, Kennedy C . Major depressive and post-traumatic stress disorder comorbidity in female victims of intimate partner violence. J Affect Disord. 2001; 66(2-3):133-8. DOI: 10.1016/s0165-0327(00)00301-3. View

Sakamoto H, Fukuda R, Okuaki T, Rogers M, Kasai K, Machida T . Parahippocampal activation evoked by masked traumatic images in posttraumatic stress disorder: a functional MRI study. Neuroimage. 2005; 26(3):813-21. DOI: 10.1016/j.neuroimage.2005.02.032. View

AUGUSTINE J . Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Brain Res Rev. 1996; 22(3):229-44. DOI: 10.1016/s0165-0173(96)00011-2. View

Carlson E, Putnam F, Ross C, Torem M, Coons P, Dill D . Validity of the Dissociative Experiences Scale in screening for multiple personality disorder: a multicenter study. Am J Psychiatry. 1993; 150(7):1030-6. DOI: 10.1176/ajp.150.7.1030. View

Phillips M, Young A, Scott S, Calder A, Andrew C, Giampietro V . Neural responses to facial and vocal expressions of fear and disgust. Proc Biol Sci. 1998; 265(1408):1809-17. PMC: 1689379. DOI: 10.1098/rspb.1998.0506. View

10.

Kemp A, Felmingham K, Das P, Hughes G, Peduto A, Bryant R . Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study. Psychiatry Res. 2007; 155(3):265-9. DOI: 10.1016/j.pscychresns.2007.01.010. View

11.

Breslau N . Gender differences in trauma and posttraumatic stress disorder. J Gend Specif Med. 2002; 5(1):34-40. View

12.

Vermetten E, Douglas Bremner J . Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder. Depress Anxiety. 2002; 16(1):14-38. DOI: 10.1002/da.10017. View

13.

Grossman R, Buchsbaum M, Yehuda R . Neuroimaging studies in post-traumatic stress disorder. Psychiatr Clin North Am. 2002; 25(2):317-40, vi. DOI: 10.1016/s0193-953x(01)00011-9. View

14.

Kremen W, Koenen K, Boake C, Purcell S, Eisen S, Franz C . Pretrauma cognitive ability and risk for posttraumatic stress disorder: a twin study. Arch Gen Psychiatry. 2007; 64(3):361-8. DOI: 10.1001/archpsyc.64.3.361. View

15.

Lanius R, Williamson P, Densmore M, Boksman K, Gupta M, Neufeld R . Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation. Am J Psychiatry. 2001; 158(11):1920-2. DOI: 10.1176/appi.ajp.158.11.1920. View

16.

Williams L, Kemp A, Felmingham K, Barton M, Olivieri G, Peduto A . Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. Neuroimage. 2005; 29(2):347-57. DOI: 10.1016/j.neuroimage.2005.03.047. View

17.

Liberzon I, Phan K . Brain-imaging studies of posttraumatic stress disorder. CNS Spectr. 2004; 8(9):641-50. DOI: 10.1017/s109285290000883x. View

18.

Gilbertson M, Paulus L, Williston S, Gurvits T, Lasko N, Pitman R . Neurocognitive function in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder. J Abnorm Psychol. 2006; 115(3):484-95. DOI: 10.1037/0021-843X.115.3.484. View

19.

Protopopescu X, Pan H, Tuescher O, Cloitre M, Goldstein M, Engelien W . Differential time courses and specificity of amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biol Psychiatry. 2005; 57(5):464-73. DOI: 10.1016/j.biopsych.2004.12.026. View

20.

Straube T, Mentzel H, Glauer M, Miltner W . Brain activation to phobia-related words in phobic subjects. Neurosci Lett. 2004; 372(3):204-8. DOI: 10.1016/j.neulet.2004.09.050. View