Colonic and Colorectal Cancer Stem Cells: Progress in the Search for Putative Biomarkers

Overview

Journal J Anat

Specialty Anatomy & Histology

Date 2008 Jul 22

PMID 18638071

Citations 16

Authors

Naomi D Willis

Stefan A Przyborski

Christopher J Hutchison

Robert G Wilson

Affiliations

Soon will be listed here.

Abstract

The maintenance of healthy colonic crypts is dependent on the integrity of the adult epithelial stem cells located within them. Perturbations in stem cell dynamics are generally believed to represent the first step towards colorectal tumorigenesis. Experimental manipulation of intestinal stem cells has greatly increased our understanding of them, but further progress has been slowed due to the absence of a reliable stem cell biomarker. In this review we discuss the candidate colonic stem cell biomarkers which have been proposed. Furthermore, we investigate the putative biomarkers for so-called colorectal cancer stem cells, a highly aggressive subpopulation of cells considered to drive tumour development.

Citing Articles

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Cancer stem cells CD133 and CD24 in colorectal cancers in Northern Iran.

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