Aging and Animal Models of Systemic Insult: Trauma, Burn, and Sepsis

Overview

Journal Shock

Date 2008 Jul 19

PMID 18636047

Citations 28

Authors

Vanessa Nomellini

Christian R Gomez

Richard L Gamelli

Elizabeth J Kovacs

Affiliations

Soon will be listed here.

Abstract

In the acute-care setting, it is widely accepted that elderly patients have increased morbidity and mortality compared with young healthy patients. The reasons for this, however, are largely unknown. Although animal modeling has helped improve treatment strategies for young patients, there are a scarce number of studies attempting to understand the mechanisms of systemic insults such as trauma, burn, and sepsis in aged individuals. This review aims to highlight the relevance of using animals to study the pathogenesis of these insults in the aged and, despite the deficiency of information, to summarize what is currently known in this field.

Citing Articles

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