Comparison of the Effects of Aging and IL-6 on the Hepatic Inflammatory Response in Two Models of Systemic Injury: Scald Injury Versus I.p. LPS Administration

Overview

Journal Shock

Date 2008 Jul 19

PMID 18636046

Citations 25

Authors

Christian R Gomez

Vanessa Nomellini

Horea Baila

Kiyoko Oshima

Elizabeth J Kovacs

Affiliations

Soon will be listed here.

Abstract

Regardless of age, a marked elevation in circulating IL-6 levels correlates with increased mortality after injury or an inflammatory challenge. We previously reported that aged IL-6 knockout mice given LPS have improved survival and reduced inflammatory response than LPS-treated aged wild type (WT) mice. Herein, we analyzed the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: dorsal scald (burn) injury versus intraperitoneal LPS administration. At 24 h after burn injury, circulating alanine aminotransferase and hepatic neutrophil accumulation were comparable regardless of age or IL-6 deficiency. However, at this same time point, these indicators of liver damage, in addition to hepatic levels of KC, a neutrophil chemoattractant, were increased in aged WT mice given LPS relative to young WT mice given LPS. The hepatic injury was drastically reduced in aged IL-6 knockout mice given LPS as compared with LPS-exposed aged WT mice. Our results suggest that the nature of the insult will determine the degree of remote injury in aged animals. In addition, the role of IL-6 as a contributing factor of tissue injury may be insult specific.

Citing Articles

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