Alpha 2.0

» Articles » PMID: 18629352

Androgen Therapy and Atherosclerotic Cardiovascular Disease

Overview

Overview

Journal Vasc Health Risk Manag

Publisher Dove Medical Press

Specialty Cardiology & Vascular Diseases

Date 2008 Jul 17

PMID 18629352

Citations 11

Authors

Authors

K-C Y McGrath

L S McRobb

A K Heather

Affiliations

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) remains the leading cause of death in Western society today. There is a striking gender difference in CVD with men predisposed to earlier onset and more severe disease. Following the recent reevaluation and ongoing debate regarding the estrogen protection hypothesis, and given that androgen use and abuse is increasing in our society, the alternate view that androgens may promote CVD in men is assuming increasing importance. Whether androgens adversely affect CVD in either men or women remains a contentious issue within both the cardiovascular and endocrinological fraternities. This review draws from basic science, animal and clinical studies to outline our current understanding regarding androgen effects on atherosclerosis, the major CVD, and asks where future directions of atherosclerosis-related androgen research may lie.

Citing Articles

Potentials of curcumin against polycystic ovary syndrome: Pharmacological insights and therapeutic promises.

Akter T, Zahan M, Nawal N, Rahman M, Tanjum T, Arafat K Heliyon. 2023; 9(6):e16957.

PMID: 37346347 PMC: 10279838. DOI: 10.1016/j.heliyon.2023.e16957.

Exploring the role of uterine fibroids in promotion of cardiovascular diseases by diabetes exposure: Findings from national health and nutrition examination survey 1999-2006.

Li B, Yuan Z, Zhang Y, Li F, Huang L, Yang Z Front Cardiovasc Med. 2022; 9:975920.

PMID: 36017104 PMC: 9395617. DOI: 10.3389/fcvm.2022.975920.

Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism.

Cheruiyot I, Olabu B, Kamau M, Ongeti K, Mandela P Anat Cell Biol. 2019; 51(4):284-291.

PMID: 30637163 PMC: 6318456. DOI: 10.5115/acb.2018.51.4.284.

The Effect of Curcumin on TNF-α, IL-6 and CRP Expression in a Model of Polycystic Ovary Syndrome as an Inflammation State.

Mohammadi S, Kayedpoor P, Karimzadeh-Bardei L, Nabiuni M J Reprod Infertil. 2017; 18(4):352-360.

PMID: 29201665 PMC: 5691251.

The genetic variation rs6903956 in the novel androgen-dependent tissue factor pathway inhibitor regulating protein () gene is not associated with levels of plasma coagulation factors in the Singaporean Chinese.

Chang X, Chin H, Quek S, Goh D, Dorajoo R, Friedlander Y Thromb J. 2017; 15:1.

PMID: 28074087 PMC: 5219704. DOI: 10.1186/s12959-016-0124-y.

References

1.

Marin P, Holmang S, Jonsson L, Sjostrom L, Kvist H, Holm G . The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int J Obes Relat Metab Disord. 1992; 16(12):991-7. View

2.

Whitsel E, Boyko E, Matsumoto A, Anawalt B, Siscovick D . Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis. Am J Med. 2001; 111(4):261-9. DOI: 10.1016/s0002-9343(01)00833-6. View

3.

Bonithon-Kopp C, Scarabin P, Bara L, Castanier M, Jacqueson A, Roger M . Relationship between sex hormones and haemostatic factors in healthy middle-aged men. Atherosclerosis. 1988; 71(1):71-6. DOI: 10.1016/0021-9150(88)90303-6. View

4.

von Dehn G, von Dehn O, Volker W, Langer C, Weinbauer G, Behre H . Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones. Horm Metab Res. 2001; 33(2):110-4. DOI: 10.1055/s-2001-12405. View

5.

Webb C, ADAMSON D, de Zeigler D, Collins P . Effect of acute testosterone on myocardial ischemia in men with coronary artery disease. Am J Cardiol. 1999; 83(3):437-9, A9. DOI: 10.1016/s0002-9149(98)00880-7. View

6.

Benten W, Guo Z, Krucken J, Wunderlich F . Rapid effects of androgens in macrophages. Steroids. 2004; 69(8-9):585-90. DOI: 10.1016/j.steroids.2004.05.007. View

7.

Nathan L, Shi W, Dinh H, Mukherjee T, Wang X, Lusis A . Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci U S A. 2001; 98(6):3589-93. PMC: 30697. DOI: 10.1073/pnas.051003698. View

8.

Haddad R, Kennedy C, Caples S, Tracz M, Bolona E, Sideras K . Testosterone and cardiovascular risk in men: a systematic review and meta-analysis of randomized placebo-controlled trials. Mayo Clin Proc. 2007; 82(1):29-39. DOI: 10.4065/82.1.29. View

9.

Maron B, Shirani J, Poliac L, Mathenge R, Roberts W, Mueller F . Sudden death in young competitive athletes. Clinical, demographic, and pathological profiles. JAMA. 1996; 276(3):199-204. View

10.

Holmang A, Svedberg J, Jennische E, Bjorntorp P . Effects of testosterone on muscle insulin sensitivity and morphology in female rats. Am J Physiol. 1990; 259(4 Pt 1):E555-60. DOI: 10.1152/ajpendo.1990.259.4.E555. View

11.

Bruck B, Brehme U, Gugel N, Hanke S, Finking G, Lutz C . Gender-specific differences in the effects of testosterone and estrogen on the development of atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1997; 17(10):2192-9. DOI: 10.1161/01.atv.17.10.2192. View

12.

Gioeli D, Ficarro S, Kwiek J, Aaronson D, Hancock M, Catling A . Androgen receptor phosphorylation. Regulation and identification of the phosphorylation sites. J Biol Chem. 2002; 277(32):29304-14. DOI: 10.1074/jbc.M204131200. View

13.

Zmuda J, Cauley J, Kriska A, Glynn N, Gutai J, Kuller L . Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. Am J Epidemiol. 1997; 146(8):609-17. DOI: 10.1093/oxfordjournals.aje.a009326. View

14.

Kupelian V, Page S, Araujo A, Travison T, Bremner W, McKinlay J . Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab. 2006; 91(3):843-50. DOI: 10.1210/jc.2005-1326. View

15.

Ng M, Quinn C, McCrohon J, Nakhla S, Jessup W, Handelsman D . Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis. J Am Coll Cardiol. 2003; 42(7):1306-13. DOI: 10.1016/j.jacc.2003.07.002. View

16.

van Kesteren P, Asscheman H, Megens J, Gooren L . Mortality and morbidity in transsexual subjects treated with cross-sex hormones. Clin Endocrinol (Oxf). 1997; 47(3):337-42. DOI: 10.1046/j.1365-2265.1997.2601068.x. View

17.

Eich D, Nestler J, Johnson D, Dworkin G, Ko D, Wechsler A . Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation. Circulation. 1993; 87(1):261-9. DOI: 10.1161/01.cir.87.1.261. View

18.

Hawk T, Zhang Y, Rajakumar G, Day A, Simpkins J . Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Res. 1998; 796(1-2):296-8. DOI: 10.1016/s0006-8993(98)00327-8. View

19.

Zhou Z, Kemppainen J, Wilson E . Identification of three proline-directed phosphorylation sites in the human androgen receptor. Mol Endocrinol. 1995; 9(5):605-15. DOI: 10.1210/mend.9.5.7565807. View

20.

Kalin M, Zumoff B . Sex hormones and coronary disease: a review of the clinical studies. Steroids. 1990; 55(8):330-52. DOI: 10.1016/0039-128x(90)90058-j. View