Injectable Iron-modified Apatitic Bone Cement Intended for Kyphoplasty: Cytocompatibility Study

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2008 Jul 16

PMID 18626750

Citations 7

Authors

M D Vlad

L J Del Valle

I Poeata

M Barraco

J Lopez

R Torres

E Fernandez

Affiliations

Soon will be listed here.

Abstract

In this study, the cytocompatibility of human ephitelial (HEp-2) cells cultured on new injectable iron-modified calcium phosphate cements (IM-CPCs) has been investigated in terms of cell adhesion, cell proliferation, and morphology. Quantitative MTT-assay and scanning electron microscopy (SEM) showed that cell adhesion and viability were not affected with culturing time by iron concentration in a dose-dependent manner. SEM-cell morphology showed that HEp-2 cells, seeded on IM-CPCs, were able to adhere, spread, and attain normal morphology. These results showed that the new injectable IM-CPCs have cytocompatible features of interest to the intended kyphophasty application, for the treatment of osteoporotic vertebral compression fractures.

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