Candida Albicans Infection Delays Duodenal Ulcer Healing in Cysteamine-induced Duodenal Ulcers in Rats

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2008 Jul 16

PMID 18622701

Citations 4

Authors

Longxue Jin

Masashi Yoshida

Tetsuya Nakamura

Hideki Ishikawa

Go Wakabayashi

Minoru Tanabe

Shigeyuki Kawachi

Masahiro Shinoda

Yoshiro Saikawa

Norihito Wada

Kaori Kameyama

Koichiro Kumai

Tetsuro Kubota

Katsuko Sano

Keisuke Nagao

Masayuki Amagai

Yuko Kitagawa

Masaki Kitajima

Affiliations

Soon will be listed here.

Abstract

A low curability of ulcers infected with Candida has been reported in the literature. The aim of the study reported here was to investigate experimentally whether Candida infection affects the healing of ulcers. Candida albicans (the Candida group) or saline (the control group) was administered intragastrically into rats with a cysteamine-induced duodenal ulcer. The duodenal lesions, vascular endothelial growth factor A (VEGF-A) and proliferating cell nuclear antigen (PCNA) were assessed. On Day 7 post-administration, 70.4% rats of the Candida group had a duodenal ulcer compared with 33.3% in the control group (P < 0.05). The duodenal ulcer in the Candida group was significantly larger and deeper than that in the control group. The number of VEGF-A- and PCNA-positive cells was smaller and the area of VEGF-A expression was lower in the Candida group. Using a rat model, we have demonstrated that Candida infection can delay the wound healing process of duodenal ulcers by means of a low expression of VEGF-A and PCNA.

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